User profiles for F. Brosseron

Frederic Brosseron

DZNE Bonn, Germany
Verified email at dzne.de
Cited by 9162

Neuroinflammation in Alzheimer's disease

…, J El Khoury, GE Landreth, F Brosseron… - The Lancet …, 2015 - thelancet.com
Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the
neuronal compartment, but includes strong interactions with immunological mechanisms in …

[HTML][HTML] Body fluid cytokine levels in mild cognitive impairment and Alzheimer's disease: a comparative overview

F Brosseron, M Krauthausen, M Kummer… - Molecular …, 2014 - Springer
This article gives a comprehensive overview of cytokine and other inflammation associated
protein levels in plasma, serum and cerebrospinal fluid (CSF) of patients with Alzheimer’s …

NLRP3 inflammasome activation drives tau pathology

…, D Tejera, A Griep, F Santarelli, F Brosseron… - Nature, 2019 - nature.com
f, Quantification of time spent in quadrant 1 (Q1) versus all other quadrants (ao) at probe trial
f, IL-1β levels in conditioned medium of primary wild-type microglia treated with LPS and 10 …

sTREM 2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Alzheimer's disease and associate with neuronal injury markers

…, L Rami, JL Molinuevo, F Brosseron… - EMBO molecular …, 2016 - embopress.org
… sTREM2 were not significantly affected by gender (F 1,521 … that CSF sTREM2 levels differed
between groups (F 2,242 … levels of CSF sTREM2 differed within these three groups (F 2,349 …

Basal forebrain atrophy along the Alzheimer's disease spectrum and its relevance for subjective cognitive decline

…, MJ Grothe, M Daamen, S Wolfsgruber, F Brosseron… - 2020 - researchsquare.com
Background There is growing evidence in the literature that the cholinergic basal forebrain
might be one of the earliest affected structures in Alzheimer’s disease (AD). Recent data …

Mediterranean diet, Alzheimer disease biomarkers, and brain atrophy in old age

…, A Schröder, S Wolfsgruber, S Altenstein, F Brosseron… - Neurology, 2021 - AAN Enterprises
Objective To determine whether following a Mediterranean-like diet (MeDi) relates to
cognitive functions and in vivo biomarkers for Alzheimer disease (AD), we analyzed cross-sectional …

[HTML][HTML] Design and first baseline data of the DZNE multicenter observational study on predementia Alzheimer's disease (DELCODE)

F Jessen, A Spottke, H Boecker, F Brosseron… - Alzheimer's research & …, 2018 - Springer
… We report the statistics for the overall group effect (F-statistic/omnibus chi-square test with p
value) and indicate significant single contrasts of each group compared to the control group, …

Instruments and methods in proteomics

C May, F Brosseron, P Chartowski… - Data Mining in …, 2011 - Springer
In the past decade, major developments in instrumentation and methodology have been
achieved in proteomics. For proteome investigations of complex biological samples derived …

Soluble Aβ oligomers and protofibrils induce NLRP3 inflammasome activation in microglia

…, I Dalgėdienė, S Schwartz, F Brosseron… - Journal of …, 2020 - Wiley Online Library
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder causing
memory loss, language problems and behavioural disturbances. AD is associated with the …

[HTML][HTML] Which features of subjective cognitive decline are related to amyloid pathology? Findings from the DELCODE study

…, P Kalbhen, MT Heneka, F Brosseron… - Alzheimer's research & …, 2019 - Springer
Background Subjective cognitive decline (SCD) has been proposed as a pre-MCI at-risk
condition of Alzheimer’s disease (AD). Current research is focusing on a refined assessment of …