User profiles for F. Capuani

Fabrizio Capuani

Istituto Nazionale di Fisica Nucleare, Università degli studi di Roma "La Sapienza"
Verified email at roma1.infn.it
Cited by 1423

Low duplicability and network fragility of cancer genes

D Rambaldi, FM Giorgi, F Capuani, A Ciliberto… - Trends in genetics, 2008 - cell.com
We identified genomic and network properties of ∼600 genes mutated in different cancer
types. These genes tend not to duplicate but, unlike most human singletons, they encode …

Threshold‐controlled ubiquitination of the EGFR directs receptor fate

…, E Maspero, F Bianchi, F Capuani… - The EMBO …, 2013 - embopress.org
How the cell converts graded signals into threshold‐activated responses is a question of
great biological relevance. Here, we uncover a nonlinear modality of epidermal growth factor …

Vesicular and non-vesicular transport feed distinct glycosylation pathways in the Golgi

…, A Varriale, S D'Auria, T Daniele, F Capuani… - Nature, 2013 - nature.com
Newly synthesized proteins and lipids are transported across the Golgi complex via different
mechanisms whose respective roles are not completely clear. We previously identified a non…

[HTML][HTML] Pathophysiology and clinical management of bile acid diarrhea

…, F Falangone, D Montanari, F Capuani… - Journal of Clinical …, 2022 - mdpi.com
Bile acid malabsorption (BAM) represents a common cause of chronic diarrhea whose
prevalence is under-investigated. We reviewed the evidence available regarding the …

[HTML][HTML] Modeling networks of coupled enzymatic reactions using the total quasi-steady state approximation

A Ciliberto, F Capuani, JJ Tyson - PLoS computational biology, 2007 - journals.plos.org
In metabolic networks, metabolites are usually present in great excess over the enzymes
that catalyze their interconversion, and describing the rates of these reactions by using the …

[HTML][HTML] The Caenorhabditis elegans Elongator Complex Regulates Neuronal α-tubulin Acetylation

…, S Marchesi, U Sauder, D Mitsushima, F Capuani… - PLoS …, 2010 - journals.plos.org
… (G) Reciprocal CoIP to (F) using anti-GFP antibody for IP and anti ELPC-1 antibody for WB.
… (F) CoIP of full length or truncated (FD) ELPC-1::GFP with endogenous α-tubulin in elpc-1(…

Discrete solution of the electrokinetic equations

F Capuani, I Pagonabarraga, D Frenkel - The Journal of chemical …, 2004 - pubs.aip.org
… to the pressure gradients as a local external force, F. Because the solutes act onto the
solvent exclusively by means of this effective force F, the hydrodynamic limit of the non-ideal- …

[HTML][HTML] Quantitative analysis reveals how EGFR activation and downregulation are coupled in normal but not in cancer cells

F Capuani, A Conte, E Argenzio, L Marchetti… - Nature …, 2015 - nature.com
Ubiquitination of the epidermal growth factor receptor (EGFR) that occurs when Cbl and
Grb2 bind to three phosphotyrosine residues (pY1045, pY1068 and pY1086) on the receptor …

A simulation study of the dynamics of a driven filament in an Aristotelian fluid

MC Lagomarsino, F Capuani, CP Lowe - Journal of theoretical biology, 2003 - Elsevier
f i on each bead consists of a bending force f iB a tension force f iT an hydrodynamic force f
iH and an “external” force f … We know that by definition ∑ i=1 N f iB = ∑ i=1 N f iT =0. Now, the …

Growth against entropy in bacterial metabolism: the phenotypic trade-off behind empirical growth rate distributions in E. coli

D De Martino, F Capuani, A De Martino - Physical biology, 2016 - iopscience.iop.org
… Daniele De Martino 5,1 , Fabrizio Capuani 2 and Andrea De Martino 3,4 … functional $S[f]=-\int
f({\bf{v}})\mathrm{log}f({\bf{v}}){\rm{d}}{\bf{v}}$ over distributions of flux vectors $f({\bf{v}})$ …