Many aspects of human physiology and behavior display rhythmicity with a period of approximately
24 h. Rhythmic changes are controlled by an endogenous time keeper, the circadian …

Alternative splicing is widely believed to have a major impact on almost all biological processes
since it increases proteome complexity and thereby controls protein function. Recently, …

Tumour necrosis factor-α (TNF-α), a proinflammatory cytokine, is a potent negative regulator
of adipocyte differentiation. However, the mechanism of TNF-α-mediated antiadipogenesis …

With recent advances in microarrays and sequencing it is now relatively straightforward to
compare pre-mRNA splicing patterns in different cellular conditions on a genome-wide scale. …

Signal-induced alternative splicing of the CD45 gene in human T cells is essential for proper
immune function. Skipping of the CD45 variable exons is controlled, in large part, by the …

… We also thank Markus Wahl and Stephan Sigrist for discussion and members of the Heyd
lab for comments on the manuscript. This work was founded through DFG grants HE5398/3 …

… Based on all SNPs we determined genetic differentiation (F ST ), genetic diversity (θ) and
short-range linkage disequilibrium (measured as r 2 ) (Fig. 1b and Extended Data Figs 3c, 5a, b…

… Rita Lima Fernandes and Dorian Mikolajczak from the AG Koksch (FU Berlin) for help with
CD spectroscopy, Sutapa Chakrabarti (FU Berlin) for discussion, and members of the Heyd …

MALT1 channels proximal T-cell receptor (TCR) signalling to downstream signalling pathways.
With MALT1A and MALT1B two conserved splice variants exist and we demonstrate here …

The formation and execution of a productive immune response requires the maturation of
competent T cells and a robust change in cellular activity upon antigen challenge. Such …