User profiles for F. Jühling
 | Frank JühlingInserm U1110, Université de Strasbourg Verified email at bioinf.uni-leipzig.de Cited by 7847 |
[HTML][HTML] Hepatitis C-related hepatocellular carcinoma in the era of new generation antivirals
Hepatitis C virus infection is a major cause of hepatocellular carcinoma worldwide. Interferon
has been the major antiviral treatment, yielding viral clearance in approximately half of …
has been the major antiviral treatment, yielding viral clearance in approximately half of …
Structure of transfer RNAs: similarity and variability
Transfer RNAs (tRNAs) are ancient molecules whose origin goes back to the beginning of
life on Earth. Key partners in the ribosome‐translation machinery, tRNAs read genetic …
life on Earth. Key partners in the ribosome‐translation machinery, tRNAs read genetic …
MITOS: improved de novo metazoan mitochondrial genome annotation
About 2000 completely sequenced mitochondrial genomes are available from the NCBI
RefSeq data base together with manually curated annotations of their protein-coding genes, …
RefSeq data base together with manually curated annotations of their protein-coding genes, …
tRNAdb 2009: compilation of tRNA sequences and tRNA genes
F Jühling, M Mörl, RK Hartmann, M Sprinzl… - Nucleic acids …, 2009 - academic.oup.com
One of the first specialized collections of nucleic acid sequences in life sciences was the ‘compilation
of tRNA sequences and sequences of tRNA genes’ ( http://www.trna.uni-bayreuth.…
of tRNA sequences and sequences of tRNA genes’ ( http://www.trna.uni-bayreuth.…
Improved annotation of protein-coding genes boundaries in metazoan mitochondrial genomes
With the rapid increase of sequenced metazoan mitochondrial genomes, a detailed manual
annotation is becoming more and more infeasible. While it is easy to identify the …
annotation is becoming more and more infeasible. While it is easy to identify the …
Metilene: fast and sensitive calling of differentially methylated regions from bisulfite sequencing data
The detection of differentially methylated regions (DMRs) is a necessary prerequisite for
characterizing different epigenetic states. We present a novel program, metilene, to identify …
characterizing different epigenetic states. We present a novel program, metilene, to identify …
Improved systematic tRNA gene annotation allows new insights into the evolution of mitochondrial tRNA structures and into the mechanisms of mitochondrial genome …
Transfer RNAs (tRNAs) are present in all types of cells as well as in organelles. tRNAs of
animal mitochondria show a low level of primary sequence conservation and exhibit ‘bizarre’ …
animal mitochondria show a low level of primary sequence conservation and exhibit ‘bizarre’ …
[HTML][HTML] HCV-induced epigenetic changes associated with liver cancer risk persist after sustained virologic response
Background & Aims Chronic hepatitis C virus (HCV) infection is an important risk factor for
hepatocellular carcinoma (HCC). Despite effective antiviral therapies, the risk for HCC is …
hepatocellular carcinoma (HCC). Despite effective antiviral therapies, the risk for HCC is …
A comprehensive analysis of bilaterian mitochondrial genomes and phylogeny
…, G Fritzsch, A Golombek, H Hadrys, F Jühling… - Molecular Phylogenetics …, 2013 - Elsevier
About 2800 mitochondrial genomes of Metazoa are present in NCBI RefSeq today, two thirds
belonging to vertebrates. Metazoan phylogeny was recently challenged by large scale EST …
belonging to vertebrates. Metazoan phylogeny was recently challenged by large scale EST …
DNA methylome analysis in Burkitt and follicular lymphomas identifies differentially methylated regions linked to somatic mutation and transcriptional control
Although Burkitt lymphomas and follicular lymphomas both have features of germinal center
B cells, they are biologically and clinically quite distinct. Here we performed whole-genome …
B cells, they are biologically and clinically quite distinct. Here we performed whole-genome …