… d–f, Fetal ovary at 15 dpc with pachytene cells indicated by arrowheads. g, h, Ovaries at 19
dpc showing pachytene cells (arrowheads) or atretic pachytene cells (arrows). i, Adult ovary. …

The presence of ribonucleotides in genomic DNA is undesirable given their increased
susceptibility to hydrolysis. Ribonuclease (RNase) H enzymes that recognize and process such …

… Reconstitution with Rnaseh2b was able to reduce cytokine and ISG responses close to
wild‐type levels (Fig 5D–F), while Rnaseh1 complementation did not (Fig 5D–F). While some …

Beta defensins are small cationic antimicrobial peptides present in the respiratory system
which have been proposed to be dysfunctional in the environment of the cystic fibrosis lung. …

DNA methylation and Polycomb are key factors in the establishment of vertebrate cellular
identity and fate. Here we report de novo missense mutations in DNMT3A, which encodes the …

… (F,G) 5C heatmaps from cells of the bodies of E11.5 wild-type embryos (F) and embryos
homozygous for the 700 kb deletion (G). Heatmap intensities represent the average of …

… (F and H) cervical vertebrae are shown dorsally (E and F) and ventrally (G and H). In E and
F… the bracket showing the compression of the mutant vertebrae (F). In G and H, the midline is …

We describe an air–liquid interface primary culture method for murine tracheal epithelial
cells on semi-permeable membranes, forming polarized epithelia with a high transepithelial …

β-defensin peptides are a family of antimicrobial peptides present at mucosal surfaces, with
the main site of expression under normal conditions in the male reproductive tract. Although …

The socio-ecological model (SEM) was first introduced as a conceptual model for understanding
human development by Urie Bronfenbrenner in the1970s and later formalized as a …