Discovering the genetic basis of a Mendelian phenotype establishes a causal link between
genotype and phenotype, making possible carrier and population screening and direct …

Purpose Mendelian disease genomic research has undergone a massive transformation
over the past decade. With increasing availability of exome and genome sequencing, the role …

We present a 6-gene, 420-species maximum-likelihood phylogeny of Ascomycota, the largest
phylum of Fungi. This analysis is the most taxonomically complete to date with species …

Congenital heart disease (CHD) patients have an increased prevalence of extracardiac
congenital anomalies (CAs) and risk of neurodevelopmental disabilities (NDDs). Exome …

The geographic and temporal origins of the domestic dog remain controversial, as genetic
data suggest a domestication process in East Asia beginning 15,000 years ago, whereas the …

INTRODUCTION Fibroblasts produce extracellular matrix (ECM) molecules that regulate
tissue strength and resilience. Imbalanced ECM maintenance leads to tissue dysfunction. …

In addition to commonly associated environmental factors, genomic factors may cause
cerebral palsy. We performed whole-exome sequencing of 250 parent–offspring trios, and …

We present a phylogenetic and phylogenomic overview of the Polyporales. The newly
sequenced genomes of Bjerkandera adusta, Ganoderma sp., and Phlebia brevispora are …

Background The rapid increase in number of sequenced genomes for species across of the
tree of life is revealing a diverse suite of orthologous genes that could potentially be …

Fungi in the class Leotiomycetes are ecologically diverse, including mycorrhizas,
endophytes of roots and leaves, plant pathogens, aquatic and aero-aquatic hyphomycetes, …