Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis

N Methia, F Louache, W Vainchenker, F Wendling - 1993 - ashpublications.org
… Souyri M, Vigon I, Penciolelli JF, Heard JM, Tambourin P, Wendling F A putative
truncated receptor gene transduced by the myeloproliferative leukemia virus immortalizes …

[PDF][PDF] Remodeling of bone marrow hematopoietic stem cell niches promotes myeloid cell expansion during premature or physiological aging

…, C Nerlov, C Ghevaert, W Vainchenker, F Louache… - Cell stem cell, 2019 - cell.com
… progenitors, b2-AR agonist did not affect early differentiation, but instead increased the
frequency of CD41hi megakaryocytic cells at a later differentiation stage (Figure S3F). …

Lipofectamine and related cationic lipids strongly improve adenoviral infection efficiency of primitive human hematopoietic cells

…, H Haddada, W Vainchenker, F Louache - Human Gene …, 1998 - liebertpub.com
Adenoviral vectors have the potential to infect a large number of cell types including quiescent
cells. Their use in hematopoietic cells is limited by the episomal form of their DNA, leading …

Deficiency in the Wiskott-Aldrich protein induces premature proplatelet formation and platelet production in the bone marrow compartment

…, A Jalil, MP Blundell, EM Cramer, F Louache… - Blood, 2006 - ashpublications.org
… Cells were then labeled by TRITC-phalloidin to visualize F-actin and VWF to confirm MK
identity and discriminate between proplatelets and pseudopodal projections that could be due …

Proplatelet formation is regulated by the Rho/ROCK pathway

…, L Momeux, J Larghero, J Bertoglio, F Louache… - Blood, 2007 - ashpublications.org
Platelets are released by megakaryocytes (MKs) via cytoplasmic extensions called proplatelets,
which require profound changes in the microtubule and actin organization. Here, we …

[HTML][HTML] Deciphering tumor niches: Lessons from solid and hematological malignancies

…, MC Le Bousse-Kerdilès, F Louache… - Frontiers in …, 2021 - frontiersin.org
Knowledge about the hematopoietic niche has evolved considerably in recent years, in
particular through in vitro analyzes, mouse models and the use of xenografts. Its complexity in …

Regulation of CCR6 chemokine receptor expression and responsiveness to macrophage inflammatory protein-3α/CCL20 in human B cells

…, A Foussat, P Galanaud, F Louache… - Blood, The Journal …, 2000 - ashpublications.org
… To determine whether CCR6 is functional in naive and memory B cells, we quantified the
change in the intracellular F-actin content induced by MIP-3α/CCL20 in cells stained with anti-…

JAK3 deregulation by activating mutations confers invasive growth advantage in extranodal nasal-type natural killer cell lymphoma

…, D Jeziorowska, L Douay, W Vainchenker, F Louache… - Leukemia, 2014 - nature.com
Extranodal, nasal-type natural killer (NK)/T-cell lymphoma (NKCL) is an aggressive malignancy
with poor prognosis in which, usually, signal transducer and activator of transcription 3 (…

The interaction between Cdc42 and WASP is required for SDF-1–induced T-lymphocyte chemotaxis

E Haddad, JL Zugaza, F Louache… - Blood, The Journal …, 2001 - ashpublications.org
In studies aimed at further characterizing the cellular immunodeficiency of the Wiskott-Aldrich
syndrome (WAS), we found that T lymphocytes from WAS patients display abnormal …

[HTML][HTML] Genetic hierarchy and temporal variegation in the clonal history of acute myeloid leukaemia

…, C Bilhou-Nabera, F Louache, F Delhommeau - Nature …, 2016 - nature.com
In acute myeloid leukaemia (AML) initiating pre-leukaemic lesions can be identified through
three major hallmarks: their early occurrence in the clone, their persistence at relapse and …