DNA mismatch repair deficiency (MMRd) is associated with a high tumor mutational burden (TMB)
and sensitivity to immune checkpoint blockade (ICB) therapy. Nevertheless, most …

Tumor behavior is intricately dependent on the oncogenic properties of cancer cells and
their multi-cellular interactions. To understand these dependencies within the wider …

Purpose Definitive radiochemotherapy (RCTX) with curative intent is one of the standard
treatment options in patients with locally advanced head and neck squamous cell carcinoma (…

… buzzatii genome with few exceptions (Negre B, Muyas F, Guillén Y, Ruiz A, in preparation).
The gene slouch is separated from the rest of the NK-C in D. buzzatii and also in all other …

Abstract Characterization of somatic mutations at single-cell resolution is essential to study
cancer evolution, clonal mosaicism and cell plasticity. Here, we describe SComatic, an …

Background Mosaic mutations acquired during early embryogenesis can lead to severe
early-onset genetic disorders and cancer predisposition, but are often undetectable in blood …

Cancers develop through somatic mutagenesis, however germline genetic variation can
markedly contribute to tumorigenesis via diverse mechanisms. We discovered and phased 88 …

In recent years, next‐generation sequencing (NGS) has become a cornerstone of clinical
genetics and diagnostics. Many clinical applications require high precision, especially if rare …

Genetic screens in cancer cell lines inform gene function and drug discovery. More
comprehensive screen datasets with multi-omics data are needed to enhance opportunities to …

The high incidence of whole-arm chromosome aneuploidy and translocations in tumors
suggests instability of centromeres, unique loci built on repetitive sequences and essential for …