Given the importance of Africa to studies of human origins and disease susceptibility, detailed
characterization of African genetic diversity is needed. The African Genome Variation …

We combined two tuberculosis genome-wide association studies from Ghana and The Gambia
with subsequent replication in a combined 11,425 individuals. rs4331426, located in a …

… Using Wright's F ST across all autosomal SNPs, we found that differences between ethnic
groups accounted for a small fraction of genetic variation within the population as a whole (F …

… Finally, we used HapMap data to demonstrate a region of low F ST (−0.001) between the …
distribution of F ST across chromosome 9 (∼99.5–99.9th centile). This low F ST region may be …

INTRODUCTION Malaria parasites cause human disease by invading and replicating inside
red blood cells. In the case of Plasmodium falciparum, this can lead to severe forms of …

Several lines of evidence link glucose-6-phosphate dehydrogenase (G6PD) deficiency to
protection from severe malaria. Early reports suggested most G6PD deficiency in sub-Saharan …

Understanding the extent to which genetic factors influence the immune response is important
in the development of subunit vaccines. Associations with HLA gene polymorphisms …

There has been much debate about the relative merits of population‐ and family‐based
strategies for testing genetic association, yet there is little empirical data that directly compare …

Host genetic factors can confer resistance against malaria 1 , raising the question of whether
this has led to evolutionary adaptation of parasite populations. Here we searched for …

Combining data from genome-wide association studies (GWAS) conducted at different
locations, using genotype imputation and fixed-effects meta-analysis, has been a powerful …