… (F. Stegmeier, unpublished data). The phosphorylation of two serine residues of Spo12 is
required for its FEAR network function. Given that these phosphorylation sites conform to the …

An increased understanding of the molecular etiology of cancer has enabled the development
of novel therapies that are collectively referred to as molecular targeted agents. Unlike the …

… f, Correlation of MDM4 exon 6 inclusion with gene expression (n = 1,003 cell lines). g,
Correlation of RPL22L1 expression with exon-inclusion ratios (n = 200–1,019; Supplementary …

… f, The effect of XAV939 on β-catenin in SW480 cells is eliminated by AXIN1/2 siRNAs. … f,
The TBD is required for XAV939-induced axin 1 protein accumulation in SW480 cells. The …

Although mechanisms of acquired resistance of epidermal growth factor receptor (EGFR)-mutant
non-small-cell lung cancers to EGFR inhibitors have been identified, little is known …

… (F) KRAS dependency profile in lung lineage colored by mutation status. On the right,
KRAS mutant lung lines only are co-plotted with KRAS, NFE2L2, and SMARCA2 dependence, …

The advent of RNA interference has led to the ability to interfere with gene expression and
greatly expanded our ability to perform genetic screens in mammalian cells. The expression …

… (f) MET copy number was assessed by quantitative PCR for groups 3–5 and control groups
treated with vehicle (group 1) or 0.2 μM crizotinib (group 2) and normalized to group 1. Bars …

Proteins are essential agents of biological processes. To date, large-scale profiling of cell line
collections including the Cancer Cell Line Encyclopedia (CCLE) has focused primarily on …

Deregulation of the PI3K signaling pathway is observed in many human cancers and occurs
most frequently through loss of PTEN phosphatase tumor suppressor function or through …