Leishmaniasis is a parasitic disease that presents four main clinical syndromes: cutaneous
leishmaniasis (CL), mucocutaneous leishmaniasis (MCL), visceral leishmaniasis/kala azar (…

The nonsense-mediated mRNA decay (NMD) pathway degrades some but not all mRNAs
bearing premature termination codons (PTCs). Decades of work have elucidated the …

Outcomes of high-throughput biological experiments are typically interpreted by statistical
testing for enriched gene functional categories defined by the Gene Ontology (GO). The …

… between methods, we calculated the F-measure (a harmonic … For each functional term f, we
calculated the area under the … The sensitivity and specificity for a particular functional term f …

Synonymous mutations change the sequence of a gene without directly altering the sequence
of the encoded protein. Here, we present evidence that these "silent" mutations frequently …

Background A major bottleneck in our understanding of the molecular underpinnings of life
is the assignment of function to proteins. While molecular experiments provide the most …

… , half-maximum growth-inhibition concentration; F, oral bioavailability in mouse after administering
… Kreusch for help with proteasome purification, and F. Luna for help with T. cruzi whole-…

Cancer genome sequencing has revealed that somatic mutation rates vary substantially
across the human genome and at scales from megabase-sized domains to individual …

… A comparison in F max between the top 5 CAFA2 models … of a CAFA3 method over a CAFA2
method in F max and (2) the … b Comparison of the performance (F max ) of Naïve baselines …

A novel Saccharomyces cerevisiae mutant, unable to grow in the presence of 12.5 mM EGTA,
was isolated by replica plating. The phenotype of the mutant is caused by a single amino …