User profiles for F. Trapani

Francesca Trapani

Boehringer Ingelheim
Verified email at boehringer-ingelheim.com
Cited by 3994

Klebsiella pneumoniae bloodstream infection: epidemiology and impact of inappropriate empirical therapy

…, S Tedeschi, F Tumietto, F Cristini, F Trapani… - Medicine, 2014 - journals.lww.com
Multidrug resistance associated with extended-spectrum beta-lactamase (ESBL) and
Klebsiella pneumoniae carbapenemase (KPC) among K. pneumoniae is endemic in southern …

Tumorigenicity and genetic profiling of circulating tumor cells in small-cell lung cancer

…, CJ Morrow, Y Li, RL Metcalf, DG Rothwell, F Trapani… - Nature medicine, 2014 - nature.com
Small-cell lung cancer (SCLC), an aggressive neuroendocrine tumor with early dissemination
and dismal prognosis, accounts for 15–20% of lung cancer cases and ∼200,000 deaths …

Epidemiology of invasive pulmonary aspergillosis among intubated patients with COVID-19: a prospective study

…, A Moroni, S Ambretti, F Trapani… - Clinical Infectious …, 2021 - academic.oup.com
Background We evaluated the incidence of invasive pulmonary aspergillosis among
intubated patients with critical COVID-19 and evaluated different case definitions of invasive …

BI-3406, a potent and selective SOS1–KRAS interaction inhibitor, is effective in KRAS-driven cancers through combined MEK inhibition

…, JR Marszalek, MP Sanderson, D Kessler, F Trapani… - Cancer Discovery, 2021 - AACR
F, In vitro sensitivity of 40 cancer cell lines treated with BI-3406 in 3-D proliferation assays. …
Images were evaluated by a pathologist (F. Trapani) and H-score was generated using …

[PDF][PDF] Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c

…, M Cornu, N Cybulski, P Polak, C Betz, F Trapani… - Cell metabolism, 2012 - cell.com
… , as suggested by an increased level of plasma glycerol (Figure S1E) and increased expression
of genes involved in lipolysis and mitochondrial oxidation in adipose tissue (Figure S1F)…

Activity of the monocarboxylate transporter 1 inhibitor AZD3965 in small cell lung cancer

…, A Fusi, D Nonaka, L Priest, P Kelly, F Trapani… - Clinical Cancer …, 2014 - AACR
Purpose: The monocarboxylate transporter 1 (MCT1) inhibitor, AZD3965, is undergoing phase
I evaluation in the United Kingdom. AZD3965 is proposed, via lactate transport modulation…

[HTML][HTML] CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer

…, H Guerston, A Barkal, F Trapani… - The Journal of …, 2016 - Am Soc Clin Investig
… (F) Summary of phagocytosis assays using human macrophages and calcein AM–labeled
SCLC cell lines (left) or primary NJH29 SCLC cells as analyzed by flow cytometry. SCLC cells …

[HTML][HTML] Vasculogenic mimicry in small cell lung cancer

SC Williamson, RL Metcalf, F Trapani, S Mohan… - Nature …, 2016 - nature.com
Small cell lung cancer (SCLC) is characterized by prevalent circulating tumour cells (CTCs),
early metastasis and poor prognosis. We show that SCLC patients (37/38) have rare CTC …

A biobank of small cell lung cancer CDX models elucidates inter-and intratumoral phenotypic heterogeneity

…, L Booth, D Morgan, M Dynowski, F Trapani… - Nature Cancer, 2020 - nature.com
Although small cell lung cancer (SCLC) is treated as a homogeneous disease, biopsies and
preclinical models reveal heterogeneity in transcriptomes and morphology. SCLC subtypes …

Dual role of tumour-infiltrating T helper 17 cells in human colorectal cancer

…, L Tornillo, P Zajac, S Eppenberger-Castori, F Trapani… - Gut, 2017 - gut.bmj.com
F Trapani2, … Sections were examined under an Olympus BX61 fluorescence microscope
(Olympus) and images captured with 10× and 20× magnifications using a F-VIEW II camera (…