Intracellular pathogens contribute to a significant proportion of infectious disease morbidity
and mortality worldwide. Increasing evidence points to a major role for host genetics in …

The major histocompatibility complex (MHC) on chromosome 6 is associated with susceptibility
to more common diseases than any other region of the human genome, including almost …

Trans-acting genetic variants have a substantial, albeit poorly characterized, role in the heritable
determination of gene expression. Using paired purified primary monocytes and B cells, …

… The protective effect of heterozygosity at the S180L locus was also significant within the
subgroup of 164 Kenyan children with pneumococcal bacteremia (F exact = 0.024, Table 1), …

Although several hundred regions of the human genome harbor signals of positive natural
selection, few of the relevant adaptive traits and variants have been elucidated. Using full-…

We combined two tuberculosis genome-wide association studies from Ghana and The Gambia
with subsequent replication in a combined 11,425 individuals. rs4331426, located in a …

After imputation of data from the 1000 Genomes Project into a genome-wide dataset of
Ghanaian individuals with tuberculosis and controls, we identified a resistance locus on …

Leprosy is an infectious disease caused by the obligate intracellular pathogen Mycobacterium
leprae and remains endemic in many parts of the world. Despite several major studies on …

It is well documented that cells secrete exosomes, which can transfer biomolecules that impact
recipient cells’ functionality in a variety of physiologic and disease processes. The role of …

Multiple genome-wide association studies (GWAS) have been performed in HIV-1 infected
individuals, identifying common genetic influences on viral control and disease course. …