Major progress in studying the biology of schistosomes had been achieved since the late
1960s with the successful laboratory cultivation of the parasite's life cycle stages in the …

Low income households living in the rural areas suffer from energy poverty and lack of human
and economic development. Currently, many governments of less developed countries …

In acute myeloid leukaemia (AML), the cell of origin, nature and biological consequences of
initiating lesions, and order of subsequent mutations remain poorly understood, as AML is …

Prostate tumours are highly variable in their response to therapies, but clinically available
prognostic factors can explain only a fraction of this heterogeneity. Here we analysed 200 …

Herein we provide a detailed molecular analysis of the spatial heterogeneity of clinically
localized, multifocal prostate cancer to delineate new oncogenes or tumor suppressors. We …

Many primary-tumor subregions have low levels of molecular oxygen, termed hypoxia.
Hypoxic tumors are at elevated risk for local failure and distant metastasis, but the molecular …

… Using linear fusion transcript information, we detected 62 fusion-circRNAs (f-circRNAs), …
recurrence for f-circRNAs, we elected to focus on canonical circRNAs, but these f-circRNAs …

Germline mutations in the BRCA2 tumour suppressor are associated with both an increased
lifetime risk of developing prostate cancer (PCa) and increased risk of aggressive disease. …

The majority of newly diagnosed prostate cancers are slow growing, with a long natural life
history. Yet a subset can metastasize with lethal consequences. We reconstructed the …

Objective The aim of this study was to evaluate the efficacy of anakinra in patients who were
admitted to hospital for severe COVID-19 pneumonia requiring oxygen therapy. Methods A …