Ageing organisms accumulate senescent cells that are thought to contribute to body dysfunction.
Telomere shortening and damage are recognized causes of cellular senescence and …

Cellular senescence, first described in vitro in 1961, has become a focus for biotech companies
that target it to ameliorate a variety of human conditions. Eminently characterized by a …

Cells continually experience stress and damage from exogenous and endogenous sources,
and their responses range from complete recovery to cell death. Proliferating cells can …

The DNA-damage response (DDR) arrests cell-cycle progression until damage is removed.
DNA-damage-induced cellular senescence is associated with persistent DDR. The …

Non-coding RNAs (ncRNAs) are involved in an increasingly recognized number of cellular
events 1. Some ncRNAs are processed by DICER and DROSHA RNases to give rise to small …

… c, d, DNA breaks accumulate in OIS cells as demonstrated by TUNEL (c) and comet assay
under denaturing conditions (d). … d, e, Stable downregulation of ATM or p53 respectively by …

Cellular senescence is associated with ageing and cancer in vivo and has a proven tumour-suppressive
function. Common to both ageing and cancer is the generation of DNA damage …

Oncogene-induced reactive oxygen species (ROS) have been proposed to be signaling
molecules that mediate proliferative cues. However, ROS may also cause DNA damage and …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the RNA virus responsible
for the coronavirus disease 2019 (COVID-19) pandemic. Although SARS-CoV-2 was …

The DNA damage response (DDR) preserves genomic integrity. Small non-coding RNAs
termed DDRNAs are generated at DNA double-strand breaks (DSBs) and are critical for DDR …