The central dogma of molecular biology entails that genetic information is transferred from
nucleic acid to proteins. Notwithstanding retro-transcribing genetic elements, DNA is …

RNA modification plays an important role in modulating host-pathogen interaction. Flavivirus
NS5 protein encodes N-7 and 2′-O methyltransferase activities that are required for the …

Microbial pathogens adapt to the stress of infection by regulating transcription, translation
and protein modification. We report that changes in gene expression in hypoxia-induced non-…

Codon bias has been implicated as one of the major factors contributing to mRNA stability
in several model organisms. However, the molecular mechanisms of codon bias on mRNA …

Here we describe an analytical platform for systems-level quantitative analysis of modified
ribonucleosides in any RNA species, with a focus on stress-induced reprogramming of tRNA …

During erythroid differentiation, the maintenance of genome integrity is key for the success
of multiple rounds of cell division. However, molecular mechanisms coordinating the …

Regnase-1-mediated mRNA decay (RMD), in which inflammatory mRNAs harboring specific
stem–loop structures are degraded, is a critical part of proper immune homeostasis. Prior to …

Background: Pulmonary arterial hypertension (PAH) is a type of pulmonary hypertension (PH)
characterized by obliterative pulmonary vascular remodeling, resulting in right-sided heart …

Regnase-1 and Roquin are RNA binding proteins that are essential for degradation of
inflammatory mRNAs and maintenance of immune homeostasis. Although deficiency of either of …

Regnase-1 is an ribonuclease that plays essential roles in restricting inflammation through
degrading messenger RNAs (mRNAs) involved in immune reactions via the recognition of …