DNA methylation is a defining feature of mammalian cellular identity and is essential for normal
development 1 , 2 . Most cell types, except germ cells and pre-implantation embryos 3 , 4 …

RnBeads is a software tool for large-scale analysis and interpretation of DNA methylation
data, providing a user-friendly analysis workflow that yields detailed hypertext reports ( http://…

DNA methylation plays a key role in regulating eukaryotic gene expression. Although
mitotically heritable and stable over time, patterns of DNA methylation frequently change in …

Systemic lupus erythematosus (SLE) is a life-threatening autoimmune disease characterized
by adaptive immune system activation, formation of double-stranded DNA autoantibodies …

Uptake and efflux transporters determine plasma and tissue concentrations of a broad variety
of drugs. They are localized in organs such as small intestine, liver, and kidney, which are …

Periconceptional diet may persistently influence DNA methylation levels with phenotypic
consequences. However, a comprehensive assessment of the characteristics of prenatal …

The International Human Epigenome Consortium (IHEC) coordinates the generation of a
catalog of high-resolution reference epigenomes of major primary human cell types. The …

DNA methylation plays an important role in development and disease. The primary sites of
DNA methylation in vertebrates are cytosines in the CpG dinucleotide context, which account …

Genetic perturbations of cortical development can lead to neurodevelopmental disease,
including autism spectrum disorder (ASD). To identify genomic regions crucial to corticogenesis, …

Background Guidelines recommend blood culture sampling from hospitalized patients with
suspected community-acquired pneumonia (CAP). However, the yield of true-positive results …