To investigate the immune response and mechanisms associated with severe coronavirus
disease 2019 (COVID-19), we performed single-cell RNA sequencing on nasopharyngeal …

Vaccines play a critical role in combating the COVID-19 pandemic. Future control of the
pandemic requires improved vaccines with high efficacy against newly emerging SARS-CoV-2 …

COVID-19-induced "acute respiratory distress syndrome" (ARDS) is associated with prolonged
respiratory failure and high mortality, but the mechanistic basis of lung injury remains …

In coronavirus disease 2019 (COVID-19), hypertension and cardiovascular diseases are
major risk factors for critical disease progression. However, the underlying causes and the …

Background The COVID-19 agent, SARS-CoV-2, is conspecific with SARS-CoV, the causal
agent of the severe acute respiratory syndrome epidemic in 2002–03. Although the viruses …

For coronavirus disease 2019 (COVID-19), effective and well-understood treatment options
are still scarce. Since vaccine efficacy is challenged by novel variants, short-lasting immunity…

Epidemiological data demonstrate that Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
variants of concern (VOCs) Alpha and Delta are more transmissible, infectious…

In COVID-19, immune responses are key in determining disease severity. However, cellular
mechanisms at the onset of inflammatory lung injury in SARS-CoV-2 infection, particularly …

Replication of viruses requires interaction with host cell factors and repression of innate
immunity. Recent findings suggest that a subset of intracellular mono-ADP-ribosylating PARPs, …

Phagocytosis by alveolar macrophages is the obligate first step in Mycobacterium tuberculosis
(Mtb) infection, yet the mechanism underlying this process is incompletely understood. …