[HTML][HTML] Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM
…, J Copps, HR Perrett, K Rantalainen, F Cannac… - Nature …, 2021 - nature.com
Engineered ectodomain trimer immunogens based on BG505 envelope glycoprotein are
widely utilized as components of HIV vaccine development platforms. In this study, we used …
widely utilized as components of HIV vaccine development platforms. In this study, we used …
[HTML][HTML] A conserved interaction between a C-terminal motif in norovirus VPg and the HEAT-1 domain of eIF4G is essential for translation initiation
…, F Sorgeloos, S Correia, Y Chaudhry, F Cannac… - PLoS …, 2016 - journals.plos.org
Translation initiation is a critical early step in the replication cycle of the positive-sense,
single-stranded RNA genome of noroviruses, a major cause of gastroenteritis in humans. …
single-stranded RNA genome of noroviruses, a major cause of gastroenteritis in humans. …
Cryo-EM structure of the Hedgehog release protein Dispatched
F Cannac, C Qi, J Falschlunger, G Hausmann… - Science …, 2020 - science.org
The Hedgehog (Hh) signaling pathway controls embryonic development and adult tissue
homeostasis in multicellular organisms. In Drosophila melanogaster, the pathway is primed by …
homeostasis in multicellular organisms. In Drosophila melanogaster, the pathway is primed by …
An evolved orthogonal enzyme/cofactor pair
EW Reynolds, MW McHenry, F Cannac… - Journal of the …, 2016 - ACS Publications
We introduce a strategy that expands the functionality of hemoproteins through orthogonal
enzyme/heme pairs. By exploiting the ability of a natural heme transport protein, ChuA, to …
enzyme/heme pairs. By exploiting the ability of a natural heme transport protein, ChuA, to …
[PDF][PDF] Structural and Functional Studies of Membrane Receptor Nucleotidyl Cyclases
F Cannac - 2019 - research-collection.ethz.ch
Membrane proteins have critical roles in the sustainability of all living organisms, performing
a wide variety of critical cellular functions. Among many other roles, they mediate and …
a wide variety of critical cellular functions. Among many other roles, they mediate and …
Correction: A conserved interaction between a C-terminal motif in norovirus VPg and the heat-1 domain of eIF4G is essential for translation initiation
…, F Sorgeloos, S Correia, Y Chaudhry, F Cannac… - PLoS …, 2016 - journals.plos.org
… Leen, Frédéric Sorgeloos, Samantha Correia, Yasmin Chaudhry, Fabien Cannac, Chiara
Pastore, Yingqi Xu, Stephen C. Graham, Stephen J. Matthews, Ian G. … Leen EN …
Pastore, Yingqi Xu, Stephen C. Graham, Stephen J. Matthews, Ian G. … Leen EN …
[PDF][PDF] Structural and functional studies of the translocator protein
E Graeber - 2018 - research-collection.ethz.ch
The Translocator Protein (TSPO) is an α-helical membrane protein that is strongly expressed
in the outer mitochondrial membrane of steroid-synthesising cells. It was first discovered as …
in the outer mitochondrial membrane of steroid-synthesising cells. It was first discovered as …
HIV envelope trimer-elicited autologous neutralizing antibodies bind a region overlapping the N332 glycan supersite
B Nogal, LE McCoy, MJ van Gils, CA Cottrell… - Science …, 2020 - science.org
To date, immunization studies of rabbits with the BG505 SOSIP.664 HIV envelope glycoprotein
trimers have revealed the 241/289 glycan hole as the dominant neutralizing antibody …
trimers have revealed the 241/289 glycan hole as the dominant neutralizing antibody …
Structural basis of sterol recognition by human hedgehog receptor PTCH1
Hedgehog signaling is central in embryonic development and tissue regeneration. Disruption
of the pathway is linked to genetic diseases and cancer. Binding of the secreted ligand, …
of the pathway is linked to genetic diseases and cancer. Binding of the secreted ligand, …
Conserved cholesterol-related activities of Dispatched 1 drive Sonic hedgehog shedding from the cell membrane
K Ehring, D Manikowski, J Goretzko… - Journal of Cell …, 2022 - journals.biologists.com
The Sonic hedgehog (Shh) pathway controls embryonic development and tissue
homeostasis after birth. Long-standing questions about this pathway include how the dual-lipidated, …
homeostasis after birth. Long-standing questions about this pathway include how the dual-lipidated, …