Mucins are a large family of heavily O-glycosylated proteins that cover all mucosal surfaces
and constitute the major macromolecules in most body fluids. Mucins are primarily defined …

Small linear motifs targeting protein interacting domains called PSD‐95/Dlg/ZO‐1 (PDZ) have
been identified at the C terminus of the severe acute respiratory syndrome coronavirus 2 (…

Human protein networks have been widely explored but most binding affinities remain
unknown, hindering quantitative interactome-function studies. Yet interactomes rely on minimal …

Microbes utilize polysaccharides to protect their surfaces and build biofilms, whereas
metazoans employ large mucins densely decorated with O-glycans to protect surfaces and keep …

PDZ domains recognize PDZ Binding Motifs (PBMs) at the extreme C-terminus of their partner
proteins. The human proteome contains 266 identified PDZ domains, the PDZome, spread …

Phosphorylation of short linear peptide motifs is a widespread process for the dynamic
regulation of protein–protein interactions. However, the global impact of phosphorylation events …

Sesquiterpene cyclases (STC) catalyse the cyclization of the C15 molecule farnesyl
diphosphate into a vast variety of mono- or polycyclic hydrocarbons and, for a few enzymes, …

Background Due to COVID-19, pandemic preparedness emerges as a key imperative,
necessitating new approaches to accelerate development of reagents against infectious …

COVID-19 continues to damage populations, communities and economies worldwide.
Vaccines have reduced COVID-19-related hospitalisations and deaths, primarily in developed …

To mount appropriate responses, T cells integrate complex sequences of receptor stimuli
perceived during transient interactions with antigen-presenting cells. Although it has been …