Generation of Interleukin (IL)-1β via cleavage of its proform requires the activity of caspase-1
(and caspase-11 in mice), but the mechanism involved in the activation of the …

Abstract Development of the acute and chronic inflammatory responses known as gout and
pseudogout are associated with the deposition of monosodium urate (MSU) or calcium …

Inflammasomes are innate immune signaling pathways that sense pathogens and injury to
direct the proteolytic maturation of inflammatory cytokines such as IL‐1β and IL‐18. Among …

Activation of caspase-1 and subsequent processing and secretion of the pro-inflammatory
cytokine IL-1β is triggered upon assembly of the inflammasome complex [1]. It is generally …

The inflammasome is a cytosolic protein complex regulating the activation of caspase-1,
which cleaves the pro-inflammatory cytokines IL-1β and IL-18 into their active form. The …

The innate immune system relies on its capacity to rapidly detect invading pathogenic microbes
as foreign and to eliminate them. The discovery of Toll-like receptors (TLRs) provided a …

Mutations within the NALP3/cryopyrin/CIAS1 gene are responsible for three autoinflammatory
disorders: Muckle-Wells syndrome, familial cold autoinflammatory syndrome, and CINCA. …

Caspases not only play an essential role during apoptotic cell death, but a subfamily of them—the
inflammatory caspases—are associated with immune responses to microbial …

Stimulation of Toll-like receptors (TLRs) initiates potent innate immune responses through
Toll–interleukin 1 receptor (TIR) domain–containing adaptors such as MyD88 and Trif. …

Sensors of pathogens, such as Toll-like receptors (TLRs), detect microbes to activate
transcriptional programs that orchestrate adaptive responses to specific insults. Here we report that …