[HTML][HTML] Reinforcement of STAT3 activity reprogrammes human embryonic stem cells to naive-like pluripotency
H Chen, I Aksoy, F Gonnot, P Osteil, M Aubry… - Nature …, 2015 - nature.com
Leukemia inhibitory factor (LIF)/STAT3 signalling is a hallmark of naive pluripotency in
rodent pluripotent stem cells (PSCs), whereas fibroblast growth factor (FGF)-2 and activin/nodal …
rodent pluripotent stem cells (PSCs), whereas fibroblast growth factor (FGF)-2 and activin/nodal …
[HTML][HTML] SERCA2 phosphorylation at serine 663 is a key regulator of Ca2+ homeostasis in heart diseases
Despite advances in cardioprotection, new therapeutic strategies capable of preventing
ischemia-reperfusion injury of patients are still needed. Here, we discover that sarcoplasmic/…
ischemia-reperfusion injury of patients are still needed. Here, we discover that sarcoplasmic/…
[HTML][HTML] Phosphorylation of cyclophilin D at serine 191 regulates mitochondrial permeability transition pore opening and cell death after ischemia-reperfusion
S Hurst, F Gonnot, M Dia, C Crola Da Silva… - Cell death & …, 2020 - nature.com
The mitochondrial permeability transition pore (mPTP) plays a critical role in the pathogenesis
of cardiovascular diseases, including ischemia/reperfusion injury. Although the pore …
of cardiovascular diseases, including ischemia/reperfusion injury. Although the pore …
[HTML][HTML] Mild therapeutic hypothermia protects from acute and chronic renal ischemia-reperfusion injury in mice by mitigated mitochondrial dysfunction and modulation …
M Schleef, F Gonnot, B Pillot, C Leon… - International Journal of …, 2022 - mdpi.com
Renal ischemia-reperfusion (IR) injury can lead to acute kidney injury, increasing the risk of
developing chronic kidney disease. We hypothesized that mild therapeutic hypothermia (…
developing chronic kidney disease. We hypothesized that mild therapeutic hypothermia (…
[HTML][HTML] High-sensitivity calcium biosensor on the mitochondrial surface reveals that IP3R channels participate in the reticular Ca2+ leak towards mitochondria
Y Gouriou, F Gonnot, M Wehbi, C Brun, L Gomez… - PLoS …, 2023 - journals.plos.org
Genetically encoded biosensors based on fluorescent proteins (FPs) are widely used to
monitor dynamics and sub-cellular spatial distribution of calcium ion (Ca 2+ ) fluxes and their …
monitor dynamics and sub-cellular spatial distribution of calcium ion (Ca 2+ ) fluxes and their …
Regulation of Cyclin E by transcription factors of the naïve pluripotency network in mouse embryonic stem cells
F Gonnot, D Langer, PY Bourillot, N Doerflinger… - Cell cycle, 2019 - Taylor & Francis
Continuous, non-cell cycle-dependent expression of cyclin E is a characteristic feature of
mouse embryonic stem cells (mESCs). We studied the 5′ regulatory region of Cyclin E, also …
mouse embryonic stem cells (mESCs). We studied the 5′ regulatory region of Cyclin E, also …
High-sensitivity calcium biosensor on the mitochondrial surface reveals that IP3R channels participate in the reticular Ca2+ leak towards mitochondria
Genetically encoded biosensors based on fluorescent proteins (FPs) are widely used to
monitor dynamics and sub-cellular spatial distribution of calcium ion (Ca 2+ ) fluxes and their …
monitor dynamics and sub-cellular spatial distribution of calcium ion (Ca 2+ ) fluxes and their …
GSK3β-Dependent Phosphorylation of CypD and PTP Regulation During Myocardial Infarction
S Hurst, F Gonnot, C Crola Da Silva, L Gomez… - Circulation, 2019 - Am Heart Assoc
Introduction: Glycogen Synthase Kinase-3β (GSK3β) plays a role in determining the
threshold for mitochondrial permeability transition pore (PTP) opening, indicating that GSK3β …
threshold for mitochondrial permeability transition pore (PTP) opening, indicating that GSK3β …
Phosphorylation of Serca2 at Serine 663, a Physiological and Clinical Event in Ischemic Heart Diseases, That Regulates Intracellular Ca2+ and Cell Death
Introduction: Despite advances in cardioprotection, new therapeutic strategies capable of
preventing acute myocardial ischemia-reperfusion injury and reducing secondary event of …
preventing acute myocardial ischemia-reperfusion injury and reducing secondary event of …
Serine 663-dependent phosphorylation of SERCA2 in ischemic heart disease: Regulation of calcium homeostasis, cell death and myocardial infarct size
Introduction Ischemic heart disease is one of the leading cause of death and disability
worldwide. Calcium handling in the post-ischemic myocardium is a prime target to treat patients …
worldwide. Calcium handling in the post-ischemic myocardium is a prime target to treat patients …