Current research in biology uses evermore complex computational and imaging tools. Here
we describe Icy, a collaborative bioimage informatics platform that combines a community …

Particle tracking is of key importance for quantitative analysis of intracellular dynamic
processes from time-lapse microscopy image data. Because manually detecting and following …

In variant Creutzfeldt–Jakob disease, prions (PrP Sc ) enter the body with contaminated
foodstuffs and can spread from the intestinal entry site to the central nervous system (CNS) by …

Synucleinopathies such as Parkinson's disease are characterized by the pathological
deposition of misfolded α‐synuclein aggregates into inclusions throughout the central and …

The study of social interactions in mice is used as a model for normal and pathological
cognitive and emotional processes. But extracting comprehensive behavioral information from …

Background In mammals, new neurons are added to the olfactory bulb (OB) throughout life.
Most of these new neurons, granule and periglomerular cells originate from the …

An imbalance between inhibitory and excitatory neurotransmission has been proposed to
contribute to altered brain function in individuals with Down syndrome (DS). Gamma-…

New interneurons are continually added to the olfactory bulb (OB), the first central relay for
processing olfactory information, throughout life. It remains unknown how these adult-…

Preclinical studies of psychiatric disorders use animal models to investigate the impact of
environmental factors or genetic mutations on complex traits such as decision-making and …

Numerous clinical reports underscore the frequency of olfactory impairments in patients
suffering from major depressive disorders (MDDs), yet the underlying physiopathological …