Soil contamination in the vicinity of the Dabaoshan Mine, Guangdong Province, China, was
studied through determination of total concentrations and chemical speciation of the toxic …

Hedgehog (Hh) signaling is deregulated in multiple human cancers including pancreatic
ductal adenocarcinoma (PDA). Because KRAS mutation represents one of the earliest genetic …

The recent discovery of Epac, a novel cAMP receptor protein, opens up a new dimension in
studying cAMP-mediated cell signaling. It is conceivable that many of the cAMP functions …

Exchange protein directly activated by cAMP (EPAC) and cAMP-dependent protein kinase (PKA)
are two intracellular receptors that mediate the effects of the prototypic second …

Epac belongs to a new family of proteins that can directly mediate the action of the intracellular
second messenger cAMP by activating a downstream small GTPase Rap1. The Epac/…

The major physiological effects of cAMP in mammalian cells are transduced by two ubiquitously
expressed intracellular cAMP receptors, protein kinase A (PKA) and exchange protein …

cAMP signaling plays a key role in regulating pain sensitivity. Here, we uncover a previously
unidentified molecular mechanism in which direct phosphorylation of the exchange protein …

Cellular transformation is a complex process involving genetic alterations associated with
multiple signaling pathways. Development of a transformation model using defined genetic …

The prototypic second messenger cyclic AMP (cAMP) is essential for controlling cellular
metabolism, including glucose and lipid homeostasis. In mammals, the majority of cAMP …

The pleiotropic second-messenger cAMP plays a crucial role in mediating the effects of
various hormones on metabolism. The major intracellular functions of cAMP are transduced by …