Autophagic degradation of the endoplasmic reticulum (ER-phagy) is triggered by ER stress
in diverse organisms. However, molecular mechanisms governing ER stress-induced ER-…

10.7554/eLife.26057.001 Spore killers in fungi are selfish genetic elements that distort
Mendelian segregation in their favor. It remains unclear how many species harbor them and how …

Macroautophagy (autophagy) is crucial for cell survival during starvation and plays important
roles in animal development and human diseases. Molecular understanding of autophagy …

Gene essentiality is a variable phenotypic trait, but to what extent and how essential genes
can become dispensable for viability remain unclear. Here, we investigate ‘bypass of …

Genetic factors underlying aging are remarkably conserved from yeast to human. The fission
yeast Schizosaccharomyces pombe is an emerging genetic model to analyze cellular aging…

The action of DNA topoisomerase II (Top2) creates transient DNA breaks that are normally
concealed inside Top2-DNA covalent complexes. Top2 poisons, including ubiquitously …

Hybridization is thought to reactivate transposable elements (TEs) that were efficiently
suppressed in the genomes of the parental hosts. Here, we provide evidence for this “genomic …

The fission yeast Schizosaccharomyces pombe is an important model organism, but its
natural diversity and evolutionary history remain under-studied. In particular, the population …

Selective macroautophagy of the endoplasmic reticulum (ER) and the nucleus, known as ER-phagy
and nucleophagy, respectively, are processes whose mechanisms remain …

Heavy metals and metalloids such as cadmium [Cd(II)] and arsenic [As(III)] are widespread
environmental toxicants responsible for multiple adverse health effects in humans. However, …