Tumor initiation and growth depend on its microenvironment in which cancer-associated
fibroblasts (CAFs) in tumor stroma play an important role. Prostaglandin E2 (PGE2) and …

Compelling evidence indicates that stress in utero, as manifested by low birth weight (LBW),
increases the risk of metabolic syndrome in adulthood. Singletons conceived by assisted …

BACKGROUND: Sr 2+ is the most efficient agent for mouse oocyte activation and functions
by inducing Ca 2+ oscillations. However, its specific mechanism of action remains unknown. …

There is evidence showing that at fertilization the sperm introduces into egg cytoplasm a
protein-based cytosolic factor, which serves as the physiological trigger for inducing Ca 2+ …

At fertilization in mammals, the sperm activates the egg by inducing a series of oscillations
in the intracellular free Ca 2+ concentration. There is evidence showing that this oscillatory …

To ascertain whether the Kunming (KM) mouse is an available model for age-related decline
in female fertility in human or not, oocytes from young (6–8 weeks), middle-aged (9 months) …

BACKGROUD: Transferring a germinal vesicle (GV) from an aged woman's oocyte into ooplasm
from a younger woman has been proposed as a possible way to overcome the problem …

Type 1 inositol 1,4,5-trisphosphate receptor (IP 3 R1) is a widely expressed intracellular
calcium-release channel found in many cell types. The operation of IP 3 R1 is regulated through …

Unsupervised domain adaptation without accessing expensive annotation processes of
target data has achieved remarkable successes in semantic segmentation. However, most …

Federated learning (FL) has attracted growing attentions via data-private collaborative training
on decentralized clients. However, most existing methods unrealistically assume object …