Tumour-activated neutrophils in gastric cancer foster immune suppression and disease progression through GM-CSF-PD-L1 pathway

T Wang, Y Zhao, L Peng, N Chen, W Chen, Y Lv, F Mao… - Gut, 2017 - gut.bmj.com
Objective Neutrophils are prominent components of solid tumours and exhibit distinct
phenotypes in different tumour microenvironments. However, the nature, regulation, function and …

Interleukin 6 induces M2 macrophage differentiation by STAT3 activation that correlates with gastric cancer progression

XL Fu, W Duan, CY Su, FY Mao, YP Lv… - Cancer Immunology …, 2017 - Springer
Interleukin 6 (IL-6) was abundant in the tumor microenvironment and played potential roles
in tumor progression. In our study, the expression of IL-6 in tumor tissues from 36 gastric …

Tumor-associated monocytes/macrophages impair NK-cell function via TGFβ1 in human gastric cancer

L Peng, J Zhang, Y Teng, Y Zhao, T Wang, F Mao… - Cancer immunology …, 2017 - AACR
Natural killer (NK) cells are a major component of the host antitumor immune response in
human cancer. However, the nature, functional regulation, and clinical relevance of NK cells in …

[HTML][HTML] Altered NKp30, NKp46, NKG2D, and DNAM-1 expression on circulating NK cells is associated with tumor progression in human gastric cancer

B Han, F Mao, Y Zhao, Y Lv, Y Teng, M Duan… - Journal of immunology …, 2018 - hindawi.com
… Bin Han, 1 Fang-yuan Mao, 2 Yong-liang Zhao, 3 Yi-pin Lv, 2 Yong-sheng Teng, 2 Mubing
Duan, 4 Weisan Chen, 4 Ping … Bin Han and Fang-yuan Mao contributed equally to this work. …

A pro-inflammatory role for Th22 cells in Helicobacter pylori-associated gastritis

…, W Li, Y Shi, W Chen, KC Pang, M Zeng, X Mao… - Gut, 2015 - gut.bmj.com
Objective Helper T (Th) cell responses are critical for the pathogenesis of Helicobacter pylori-induced
gastritis. Th22 cells represent a newly discovered Th cell subset, but their …

[HTML][HTML] Altered phenotypic and functional characteristics of CD3+ CD56+ NKT-like cells in human gastric cancer

L Peng, F Mao, Y Zhao, T Wang, N Chen, J Zhang… - Oncotarget, 2016 - ncbi.nlm.nih.gov
CD3+ CD56+ natural killer T (NKT)-like cells are a group of CD3+ T cells sharing characteristics
of NK and T cells and constitute a major component of host anti-tumor immune response …

Helicobacter pylori–induced matrix metallopeptidase-10 promotes gastric bacterial colonization and gastritis

Y Lv, P Cheng, J Zhang, F Mao, Y Teng, Y Liu… - Science …, 2019 - science.org
The interaction between gastric epithelium and immune response plays key roles in H. pylori–associated
pathology. We demonstrated a procolonization and proinflammation role of …

[HTML][HTML] CD45+CD33lowCD11bdim myeloid-derived suppressor cells suppress CD8+ T cell activity via the IL-6/IL-8-arginase I axis in human gastric cancer

F Mao, Y Zhao, Y Lv, Y Teng, H Kong, Y Liu, X Wu… - Cell death & …, 2018 - nature.com
Myeloid-derived suppressor cells (MDSCs) are a prominent component of the pro-tumoral
response. The phenotype of and mechanisms used by MDSCs is heterogeneous and requires …

[HTML][HTML] Increased tumor-infiltrating CD45RA− CCR7− regulatory T-cell subset with immunosuppressive properties foster gastric cancer progress

F Mao, H Kong, Y Zhao, L Peng, W Chen, J Zhang… - Cell death & …, 2017 - nature.com
Regulatory T cells (Tregs) are major components of tumor-infiltrating immune cells with
potent immunosuppressive properties in gastric cancer (GC) microenvironment. However, …

[HTML][HTML] Degranulation of mast cells induced by gastric cancer-derived adrenomedullin prompts gastric cancer progression

…, Q Wang, N Chen, Y Teng, T Wang, F Mao… - Cell death & …, 2018 - nature.com
Mast cells are prominent components of solid tumors and exhibit distinct phenotypes in
different tumor microenvironments. However, their precise mechanism of communication in …