The mouse embryo undergoes compaction at the 8-cell stage, and its transition to 16 cells
generates polarity such that the outer apical cells are trophectoderm (TE) precursors and the …

Transcriptional control requires epigenetic changes directed by mitochondrial tricarboxylic
acid (TCA) cycle metabolites. In the mouse embryo, global epigenetic changes occur during …

PI3K/AKT signaling is known to regulate cancer metabolism, but whether metabolic feedback
regulates the PI3K/AKT pathway is unclear. Here, we demonstrate the important reciprocal …

The mechanistic target of rapamycin complex 1 (mTORC1) controls cell growth in response
to amino acid and glucose levels. However, how mTORC1 senses glucose availability to …

Mammalian preimplantation embryos follow a stereotypic pattern of development from zygotes
to blastocysts. Here, we use labeled nutrient isotopologue analysis of small numbers of …

The Hippo tumor suppressor pathway plays important roles in organ size control through
Lats1/2 mediated phosphorylation of the YAP/TAZ transcription co-activators. However, YAP/…

Stem cells and progenitor cells are the cells of origin for multi-cellular organisms and organs.
They play key roles during development and their dysregulation gives rise to human …

Genetic and genomic analysis in Drosophila suggests that hematopoietic progenitors likely
transition into terminal fates via intermediate progenitors (IPs) with some characteristics of …

Maintenance of energy level to drive movements and material exchange with the environment
is a basic principle of life. AMP-activated protein kinase (AMPK) senses energy level and …

A Gram-stain-negative, non-motile and aerobic bacterium, designated CF17 T , was
isolated from coastal planktonic seaweeds, East China Sea. The isolate grew at 18–37 C (optimum …