Introduction We investigated plasma proteomic markers of astrocytopathy, brain degeneration,
plasticity, and inflammation in sporadic early-onset versus late-onset Alzheimer's disease …

Exosomes are nanovesicles secreted by virtually all cells. Exosomes mediate the horizontal
transfer of various macromolecules previously believed to be cell-autonomous in nature, …

The most definitive classification systems for dementia are based on the underlying pathology
which, in turn, is categorized largely according to the observed accumulation of abnormal …

Alzheimer’s disease is an incurable neurodegenerative disorder in which neuroinflammation
has a critical function 1 . However, little is known about the contribution of the adaptive …

Objective To evaluate trials of drugs that target amyloid to determine whether reductions in
amyloid levels are likely to improve cognition. Design Instrumental variable meta-analysis. …

The default mode network (DMN) supports memory functioning and may be sensitive to
preclinical Alzheimer's pathology. Little is known, however, about the longitudinal trajectory of …

Mutations in the FOXP2 gene cause a severe communication disorder involving speech
deficits (developmental verbal dyspraxia), accompanied by wide-ranging impairments in …

Cardiovascular (CV)-and lifestyle-associated risk factors (RFs) are increasingly recognized
as important for Alzheimer’s disease (AD) pathogenesis. Beyond the ε4 allele of …

Clinical trials focusing on therapeutic candidates that modify β-amyloid (Aβ) have repeatedly
failed to treat Alzheimer’s disease (AD), suggesting that Aβ may not be the optimal target for …

Although the diagnosis of dementia still is primarily based on clinical criteria, neuroimaging
is playing an increasingly important role. This is in large part due to advances in techniques …