The decompaction and re-establishment of chromatin organization immediately after mitosis
is essential for genome regulation. Mechanisms underlying chromatin structure control in …

Among other targets, the protein lysine methyltransferase PR ‐Set7 induces histone H4
lysine 20 monomethylation (H4K20me1), which is the substrate for further methylation by the …

Nahuoic acids A–E (1–5) have been isolated from laboratory cultures of a Streptomyces sp.
obtained from a tropical marine sediment. The structures of the new polyketides 2–5 were …

Background Multiple myeloma (MM) is a malignancy of plasma cells that largely remains
incurable. The search for new therapeutic targets is therefore essential. In addition to a wide …

Cyclin A2 is a key player in the regulation of the cell cycle. Its degradation in mid-mitosis
depends primarily on the ubiquitin-proteasome system (UPS), while autophagy also contributes. …

Multiple myeloma (MM) is a malignancy of plasma cells that largely remains incurable. The
search for new therapeutic targets is therefore essential. Here we show that a higher …

Epigenetic regulation mechanisms - such as histone marks, DNA methylation and miRNA -
are often misregulated in cancers and are associated with tumorigenesis and drug resistance…

In eukaryotes, the deoxyribonucleic acid (DNA) molecule is associated with nuclear proteins
called histones to form chromatin. This structure is not only essential to compact DNA to fit …

… Sarah Izard Smith, Rita Izard Hunter, and Laura Izard Harris, … senator, Ralph Izard, and his
wife, Alice deLancey Izard. The … by relatives of the three Izard sisters after the receipt of the …

T he past, as the folklorist Henry Glassie put it,“has vanished, leaving scars, tracks, stains,”
the memories, documents, shards, buildings, footprints of vanished structures, furnishings, …