For a long time, viruses have been shown to modify the clinical picture of several
autoimmune diseases, including type 1 diabetes (T1D), systemic lupus erythematosus (SLE), …

The treatment of several solid and hematologic malignancies with immune checkpoint
inhibitors (against programmed death receptor-1/ligand-1 [PD-1/PD-L1]) has dramatically …

Breast cancer was traditionally not considered a particularly immunogenic tumor. However,
recent developments have shown that some aggressive triple-negative breast cancers are …

Antibody-dependent enhancement (ADE) has been associated with severe disease outcomes
in several viral infections, including respiratory infections. In vitro and in vivo studies …

Oncoviruses are implicated in around 20% of all human cancers including both solid and
non-solid malignancies. Epstein–Barr virus (EBV) and human papillomaviruses (HPVs) are the …

Great strides have been made in triple negative breast cancer (TNBC) treatment, which
represents 20% of total predicted annual US breast cancer (BC) cases. Despite the development …

Metabolic dysregulation in the hypoxic tumor microenvironment (TME) is considered as a
hallmark of solid tumors, leading to changes in biosynthetic pathways favoring onset, survival …

Coronavirus disease-2019 (COVID-19) was declared as a pandemic by WHO in March 2020.
SARS-CoV-2 causes a wide range of illness from asymptomatic to life-threatening. There …

We generated a transgenic mouse strain (LSL‐TβRI CA ) containing a latent constitutively
active TGFβ type I receptor (TβRI/ALK5) by using a knock‐in strategy into the X chromosome‐…

Waning immunity following administration of mRNA-based COVID-19 vaccines remains a
concern for many health systems. We undertook a study to determine if recent reports of …