Wolfram syndrome is an autosomal recessive neurodegenerative disorder characterized by
juvenile-onset diabetes mellitus and progressive optic atrophy. mtDNA deletions have been …

Wolfram syndrome (WS) is the inherited association of juvenile‐onset insulin‐dependant
diabetes mellitus and progressive bilateral optic atrophy. A nuclear gene, WFS1/wolframin, was …

While Epstein-Barr virus (EBV) infection is associated with the development of certain
lymphoid and epithelial tumors, the role of the virus in the pathogenesis of these malignancies …

Ingenol 3-angelate (PEP005) is a selective small molecule activator of protein kinase C (PKC)
extracted from the plant Euphorbia peplus, whose sap has been used as a traditional …

Combined bezafibrate (BEZ) and medroxyprogesterone acetate (MPA) exert unexpected
antileukaemic activities against acute myeloid leukaemia (AML) and these activities are …

We hypothesized that key antiproliferative target genes for the vitamin D receptor (VDR)
were repressed by an epigenetic mechanism in prostate cancer cells resulting in apparent …

The human epidermis is a self-renewing epithelial tissue composed of several layers of
keratinocytes. Within the epidermis there exists a complex array of cell adhesion structures, and …

The aldo-keto reductase AKR1C3, has been shown to regulate myelopoiesis via its ability to
metabolise prostaglandin D 2 (PGD 2 ). Other studies have demonstrated the oxidative …

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic has caused
a significant number of fatalities and worldwide disruption. To identify drugs to repurpose to …

The redeployed drug combination of bezafibrate and medroxyprogesterone acetate (designated
BaP) has potent in vivo anticancer activity in acute myelogenous leukemia (AML) and …