The endoplasmic reticulum (ER) is a key regulator of cellular proteostasis because it controls
folding, sorting, and degradation of secretory proteins. Much has been learned about how …

Endoplasmic Reticulum (ER) stress signaling is an adaptive mechanism triggered when
protein folding demand overcomes the folding capacity of this compartment, thereby leading to …

Background and Aims Netrin‐1 displays protumoral properties, though the pathological contexts
and processes involved in its induction remain understudied. The liver is a major model …

In the past decades, many studies reported the presence of endoplasmic reticulum (ER)‐resident
proteins in the cytosol. However, the mechanisms by which these proteins relocate and …

The synthesis, quality control, and trafficking of a third of the eukaryotic proteome takes
place at the endoplasmic reticulum (ER), which is the largest cellular organelle. Thus, …

It is becoming increasingly evident that reactive oxygen species (ROS) have critical roles as
“second messengers” in cell signaling. In B cells, ROS can be generated either as a …

ER stress is mediated by three sensors and the most evolutionary conserved IRE1α signals
through its cytosolic kinase and endoribonuclease (RNase) activities. IRE1α RNase activity …

Hepatitis C virus (HCV) virions contain a subset of host liver cells proteome often composed
of interesting virus-interacting factors. A proteomic analysis performed on double gradient-…

Past research on secretory pathway (SP) provided a deep understanding of the core components
that control trafficking between organelles as well as their architecture. However, it is …

Breast cancer progression is a complex process controlled by genetic and epigenetic
factors that coordinate the crosstalk between tumor cells and the components of tumor …