Background The human gut microbiome performs important functions in human health and
disease. A classic example for host-gut microbial co-metabolism is host biosynthesis of …

Recent advances focusing on the metabolic interactions within and between cellular
populations have emphasized the importance of microbial communities for human health. …

Background Parkinson’s disease (PD) is a systemic disease clinically defined by the
degeneration of dopaminergic neurons in the brain. While alterations in the gut microbiome …

Parkinson's disease (PD) exhibits systemic effects on the human metabolism, with emerging
roles for the gut microbiome. Here, we integrate longitudinal metabolome data from 30 drug-…

Motivation The application of constraint-based modeling to functionally analyze metagenomic
data has been limited so far, partially due to the absence of suitable toolboxes. Results To …

Spontaneous preterm birth (sPTB) is a leading cause of maternal and neonatal morbidity and
mortality, yet its prevention and early risk stratification are limited. Previous investigations …

Background Whilst there has been progress in supportive treatment for traumatic brain injury
(TBI), specific neuroprotective interventions are lacking. Models of ischaemic heart and …

The human gut microbiome performs important functions human health and disease.
Intestinal microbes are capable of deconjugation and biotransformation of human primary bile …

Background: Esophageal adenocarcinoma (EAC) is rising in incidence, and established risk
factors do not explain this trend. Esophageal microbiome alterations have been associated …

Microbially-produced metabolites and microbiome metabolism in general are strongly linked
to ecosystem-level phenotypes, including the health of the human host (Bar et al., 2020; …