Antioxidant enzymes form the first line of defense against free radicals in organisms. Their
regulation depends mainly on the oxidant status of the cell, given that oxidants are their …

It is well established that melatonin exerts antitumoral effects in many cancer types, mostly
decreasing cell proliferation at low concentrations. On the other hand, induction of apoptosis …

Background The simultaneous accumulation of different misfolded proteins in the central
nervous system is a common feature in many neurodegenerative diseases. In most cases, co-…

Parkinson’s disease is a chronic condition characterized by cell death of dopaminergic neurons
mainly in the substantia nigra. Among the several experimental models used in mice for …

Melatonin is an indolamine mostly produced in the pineal gland, soluble in water, and highly
lipophilic, which allows it to readily cross the blood-brain barrier. Melatonin possesses …

Low concentrations (nanomolar) of melatonin had been previously shown to inhibit cell
proliferation in several cancer cell lines as well as in experimental animal models. Additionally, …

We developed a new cell model for the visualization of toxic huntingtin oligomers in living
cells. Huntingtin exon 1 (25Q or 103Q) was fused to non-fluorescent halves of the Venus …

Tau abnormalities play a central role in several neurodegenerative diseases, collectively
known as tauopathies. In the present study, we examined whether mutant huntingtin (mHtt), …

The microtubule-associated protein tau is implicated in the formation of oligomers and fibrillar
aggregates that evade proteostasis control and spread from cell-to-cell. Tau pathology is …

Several oncogenic pathways plus local microenvironmental conditions, such as hypoxia,
converge on the regulation of cancer cells metabolism. The major metabolic alteration consists …