User profiles for Felipe Cava

Felipe Cava

Umeå University (Sweden)
Verified email at umu.se
Cited by 8124

D-amino acids govern stationary phase cell wall remodeling in bacteria

H Lam, DC Oh, F Cava, CN Takacs, J Clardy… - Science, 2009 - science.org
In all known organisms, amino acids are predominantly thought to be synthesized and used
as their L-enantiomers. Here, we found that bacteria produce diverse D-amino acids as well, …

In Situ Probing of Newly Synthesized Peptidoglycan in Live Bacteria with Fluorescent D‐Amino Acids

…, PJ Brown, E Hall, S Tekkam, F Cava… - Angewandte …, 2012 - Wiley Online Library
Bacterial growth is controlled by the peptidoglycan (PG) cell wall, a rigid and essential
structure composed of glycan strands cross-linked by d-amino acid (DAA)-containing short …

d-Amino Acid Chemical Reporters Reveal Peptidoglycan Dynamics of an Intracellular Pathogen

…, S Whiteside, JC Jewett, A Aditham, F Cava… - ACS chemical …, 2013 - ACS Publications
Peptidoglycan (PG) is an essential component of the bacterial cell wall. Although
experiments with organisms in vitro have yielded a wealth of information on PG synthesis and …

[HTML][HTML] Emerging knowledge of regulatory roles of d-amino acids in bacteria

F Cava, H Lam, MA De Pedro, MK Waldor - Cellular and Molecular Life …, 2011 - Springer
The d-enantiomers of amino acids have been thought to have relatively minor functions in
biological processes. While l-amino acids clearly predominate in nature, d-amino acids are …

Pathogen-mediated manipulation of arthropod microbiota to promote infection

…, JM Ansari, KK Jefferson, F Cava… - Proceedings of the …, 2017 - National Acad Sciences
Arthropods transmit diverse infectious agents; however, the ways microbes influence their
vector to enhance colonization are poorly understood. Ixodes scapularis ticks harbor …

Distinct pathways for modification of the bacterial cell wall by non‐canonical d‐amino acids

F Cava, MA De Pedro, H Lam, BM Davis… - The EMBO …, 2011 - embopress.org
Production of non‐canonical d‐amino acids (NCDAAs) in stationary phase promotes remodelling
of peptidoglycan (PG), the polymer that comprises the bacterial cell wall. Impairment of …

Mechanisms of Incorporation for D-Amino Acid Probes That Target Peptidoglycan Biosynthesis

…, G Booher, E Breukink, DI Roper, F Cava… - ACS Chemical …, 2019 - ACS Publications
Bacteria exhibit a myriad of different morphologies, through the synthesis and modification
of their essential peptidoglycan (PG) cell wall. Our discovery of a fluorescent D-amino acid (…

[HTML][HTML] Anammox Planctomycetes have a peptidoglycan cell wall

…, RJ Mesman, E Kuru, A Espaillat, F Cava… - Nature …, 2015 - nature.com
Planctomycetes are intriguing microorganisms that apparently lack peptidoglycan, a
structure that controls the shape and integrity of almost all bacterial cells. Therefore, the …

Thermus thermophilus as biological model

F Cava, A Hidalgo, J Berenguer - Extremophiles, 2009 - Springer
Thermus spp is one of the most wide spread genuses of thermophilic bacteria, with isolates
found in natural as well as in man-made thermal environments. The high growth rates, cell …

Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus

…, P Richaud, R Voulhoux, A Espaillat, F Cava… - Science, 2016 - science.org
Metal acquisition is a vital microbial process in metal-scarce environments, such as inside a
host. Using metabolomic exploration, targeted mutagenesis, and biochemical analysis, we …