A tethered delivery mechanism explains the catalytic action of a microtubule polymerase
10.7554/eLife.03069.001 Stu2p/XMAP215 proteins are essential microtubule polymerases
that use multiple αβ-tubulin-interacting TOG domains to bind microtubule plus ends and …
that use multiple αβ-tubulin-interacting TOG domains to bind microtubule plus ends and …
The Human Nose Organoid Respiratory Virus Model: an Ex Vivo Human Challenge Model To Study Respiratory Syncytial Virus (RSV) and Severe Acute Respiratory …
…, SF Venable, T McBride, L Aideyan, FA Piedra… - MBio, 2022 - Am Soc Microbiol
There is an unmet need for preclinical models to understand the pathogenesis of human
respiratory viruses and predict responsiveness to immunotherapies. Airway organoids can …
respiratory viruses and predict responsiveness to immunotherapies. Airway organoids can …
[HTML][HTML] The interdependencies of viral load, the innate immune response, and clinical outcome in children presenting to the emergency department with respiratory …
FA Piedra, M Mei, V Avadhanula, R Mehta, L Aideyan… - PloS one, 2017 - journals.plos.org
Respiratory syncytial virus (RSV) causes significant infant morbidity and mortality. For decades
severe RSV-induced disease was thought to result from an uncontrolled host response to …
severe RSV-induced disease was thought to result from an uncontrolled host response to …
GDP-to-GTP exchange on the microtubule end can contribute to the frequency of catastrophe
FA Piedra, T Kim, ES Garza, EA Geyer… - Molecular biology of …, 2016 - Am Soc Cell Biol
Microtubules are dynamic polymers of αβ-tubulin that have essential roles in chromosome
segregation and organization of the cytoplasm. Catastrophe—the switch from growing to …
segregation and organization of the cytoplasm. Catastrophe—the switch from growing to …
Multiple respiratory syncytial virus (RSV) strains infecting HEp-2 and A549 cells reveal cell line-dependent differences in resistance to RSV infection
A Rajan, FA Piedra, L Aideyan, T McBride… - Journal of …, 2022 - Am Soc Microbiol
… Azzi JM, Aideyan L, Mei M, Piedra PA. 2015. Infection with novel respiratory syncytial …
Felipe-Andrés Piedra … Anubama Rajan and Felipe-Andrés Piedra contributed equally to this …
Felipe-Andrés Piedra … Anubama Rajan and Felipe-Andrés Piedra contributed equally to this …
A mutation uncouples the tubulin conformational and GTPase cycles, revealing allosteric control of microtubule dynamics
EA Geyer, A Burns, BA Lalonde, X Ye, FA Piedra… - Elife, 2015 - elifesciences.org
10.7554/eLife.10113.001 Microtubule dynamic instability depends on the GTPase activity of
the polymerizing αβ-tubulin subunits, which cycle through at least three distinct …
the polymerizing αβ-tubulin subunits, which cycle through at least three distinct …
[HTML][HTML] Non-gradient and genotype-dependent patterns of RSV gene expression
FA Piedra, X Qiu, MN Teng, V Avadhanula… - PLoS …, 2020 - journals.plos.org
Respiratory syncytial virus (RSV) is a nonsegmented negative-strand RNA virus (NSV) and
a leading cause of severe lower respiratory tract illness in infants and the elderly. …
a leading cause of severe lower respiratory tract illness in infants and the elderly. …
[HTML][HTML] Oligonucleotide capture sequencing of the SARS-CoV-2 genome and subgenomic fragments from COVID-19 individuals
The newly emerged and rapidly spreading SARS-CoV-2 causes coronavirus disease 2019 (COVID-19).
To facilitate a deeper understanding of the viral biology we developed a capture …
To facilitate a deeper understanding of the viral biology we developed a capture …
Viral load of severe acute respiratory syndrome coronavirus 2 in adults during the first and second wave of coronavirus disease 2019 pandemic in Houston, Texas: the …
…, EG Nicholson, L Ferlic-Stark, FA Piedra… - The Journal of …, 2021 - academic.oup.com
Background During the coronavirus disease 2019 pandemic, a minority of index cases are
associated with a majority of secondary cases suggesting that superspreaders could drive the …
associated with a majority of secondary cases suggesting that superspreaders could drive the …
The human nose organoid respiratory virus model: an ex-vivo human challenge model to study RSV and SARS-CoV-2 pathogenesis and evaluate therapeutics
…, SF Venable, T McBride, L Aideyan, FA Piedra… - bioRxiv, 2021 - biorxiv.org
There is an unmet need for pre-clinical models to understand the pathogenesis of human
respiratory viruses; and predict responsiveness to immunotherapies. Airway organoids can …
respiratory viruses; and predict responsiveness to immunotherapies. Airway organoids can …