Regulatory T cells (T reg cells) perform two distinct functions: they maintain self-tolerance,
and they support organ homeostasis by differentiating into specialized tissue T reg cells. We …

Tumour heterogeneity encompasses both the malignant cells and their microenvironment.
While heterogeneity between individual patients is known to affect the efficacy of cancer …

Chitin is the second most abundant polysaccharide in nature and linked to fungal infection
and asthma. However, bona fide immune receptors directly binding chitin and signaling …

Hematopoietic stem cells (HSCs) mediate regeneration of the hematopoietic system following
injury, such as following infection or inflammation. These challenges impair HSC function, …

The cells and mechanisms involved in blood clot resorption are only partially known. We
show that regulatory T cells (Tregs) accumulate in venous blood clots and regulate …

Background Interventional trials in amyotrophic lateral sclerosis (ALS) suffer from the
heterogeneity of the disease as it considerably reduces statistical power. We asked if blood …

Multicellular organisms require specialized cell types in order to function. While a widely
accepted definition does not exist, cell types are regarded as groups of cells with similar …

Hematopoietic stem cells (HSCs) are canonically defined by their capacity to maintain the
HSC pool via self-renewal divisions. However, accumulating evidence suggests that HSC …

… Michael Delacher, Charles D Imbusch, Dieter Weichenhan, Achim Breiling, Agnes Hotz-Wagenblatt,
Ulrike Träger, Ann-Cathrin Hofer, Danny Kägebein, Qi Wang, Felix Frauhammer, Jan-Philipp …

Chitin is a highly abundant polysaccharide and linked to fungal infection and asthma.
Unfortunately, its polymeric structure has hampered the identification of immune receptors directly …