For more than 100 years, the fruit fly Drosophila melanogaster has been one of the most
studied model organisms. Here, we present a single-cell atlas of the adult fly, Tabula …

Antibody memory protects humans from many diseases. Protective antibody memory responses
require activation of transcriptional programs, cell proliferation, and production of antigen…

Tumor evolution is driven by the progressive acquisition of genetic and epigenetic alterations
that enable uncontrolled growth and expansion to neighboring and distal tissues. The …

10.7554/eLife.16578.001 Antibody class switching is a feature of the adaptive immune system
which enables diversification of the effector properties of antibodies. Even though class …

Despite the vast diversity of the antibody repertoire, infected individuals often mount antibody
responses to precisely the same epitopes within antigens. The immunological mechanisms …

The definition of neuronal type and how it relates to the transcriptome are open questions.
Drosophila olfactory projection neurons (PNs) are among the best-characterized neuronal …

A system for programmable export of RNA molecules from living cells would enable both
non-destructive monitoring of cell dynamics and engineering of cells capable of delivering …

Recognition of environmental cues is essential for the survival of all organisms. Transcriptional
changes occur to enable the generation and function of the neural circuits underlying …

Antibodies are created and refined by somatic evolution in B cell populations, which endows
the human immune system with the ability to recognize and eliminate diverse pathogens. …

Transposable elements (TEs) are ubiquitous genomic parasites that have prompted the
evolution of genome defense systems that restrict their activity. Repeat-induced point mutation (…