Individual reports suggest that the central nervous system (CNS) contains multiple immune
cell types with diverse roles in tissue homeostasis, immune defense, and neurological …

Immune-checkpoint blockade has revolutionized cancer therapy. In particular, inhibition of
programmed cell death protein 1 (PD-1) has been found to be effective for the treatment of …

Granulocyte-macrophage colony-stimulating factor (GM-CSF) has emerged as a crucial
cytokine produced by auto-reactive T helper (Th) cells that initiate tissue inflammation. Multiple …

High-dimensional mass and flow cytometry (HDCyto) experiments have become a method
of choice for high-throughput interrogation and characterization of cell populations. Here, we …

Cellular metabolism regulates immune cell activation, differentiation and effector functions,
but current metabolic approaches lack single-cell resolution and simultaneous …

B cells are capable of a wide range of effector functions including antibody secretion, antigen
presentation, cytokine production, and generation of immunological memory. A consistent …

Ever since its invention half a century ago, flow cytometry has been a major tool for single‐cell
analysis, fueling advances in our understanding of a variety of complex cellular systems, …

Genome-wide association studies implicate dysregulation of immune mechanisms in the
pathogenesis of multiple sclerosis (MS). Particularly, polymorphisms in genes involved in T …

Cytokine dysregulation is a central driver of chronic inflammatory diseases such as multiple
sclerosis (MS). Here, we sought to determine the characteristic cellular and cytokine …

The cellular complexity and functional diversity of the human immune system necessitate the
use of high-dimensional single-cell tools to uncover its role in multifaceted diseases such …