In prokaryotes and eukaryotes, most genes appear to be transcribed during short periods
called transcriptional bursts, interspersed by silent intervals. We describe how such bursts …

Mammalian genes are often transcribed discontinuously as short bursts of RNA synthesis
followed by longer silent periods. However, how these “on” and “off” transitions, together with …

The mammalian circadian timing system is composed of a central pacemaker in the
suprachiasmatic nucleus (SCN) of the brain and subsidiary oscillators in most peripheral cell types. …

Background Odorant receptors (ORs) are thought to act in a combinatorial fashion, in which
odor identity is encoded by the activation of a subset of ORs and the olfactory sensory …

In yeast, ribosome production is controlled transcriptionally by tight coregulation of the 138
ribosomal protein genes (RPGs). RPG promoters display limited sequence homology, and …

The molecular mechanism underlying pluripotency is largely unknown. Here, we provide the
first global transcriptional profile of the state of “stemness” in human embryonic stem cells (…

The mammalian circadian clock uses interlocked negative feedback loops in which the
heterodimeric basic helix-loop-helix transcription factor BMAL1/CLOCK is a master regulator. …

Mechanisms composing Drosophila's clock are conserved within the animal kingdom. To
learn how such clocks influence behavioral and physiological rhythms, we determined the …

During early mouse development, the subtilisin-like proprotein convertases (SPC) Furin and
PACE4 pattern the primitive ectoderm and visceral endoderm, presumably by activating the …

The circadian clock in animals orchestrates widespread oscillatory gene expression programs,
which underlie 24-h rhythms in behavior and physiology. Several studies have shown the …