Intrinsically disordered proteins often form dynamic complexes with their ligands. Yet, the
speed and amplitude of these motions are hidden in classical binding kinetics. Here, we …

Allostery is a pervasive principle to regulate protein function. Growing evidence suggests
that also DNA is capable of transmitting allosteric signals. Yet, whether and how DNA-…

Membrane proteins require lipid bilayers for function. While lipid compositions reach enormous
complexities, high‐resolution structures are usually obtained in artificial detergents. To …

Specific protein interactions typically require well-shaped binding interfaces. Here, we
report a cunning exception. The disordered tail of the cell-adhesion protein E-cadherin …

Flexibility in complexes between intrinsically disordered proteins and folded ligands is
widespread in nature. However, timescales and spatial amplitudes of such dynamics remained …

Intrinsically disordered proteins often form dynamic complexes with their ligands. Yet, speed
and amplitude of these motions are hidden in classical binding kinetics. Here, we directly …

Gene networks often obey complex dynamics such as pulsing and oscillations that require a
nearly binary “on” and “off” switch in gene activity. At a molecular level, a high cooperativity …

While structural biology aims at explaining the biological function of membrane proteins
with their structure, it is unclear how these proteins are modulated by the complex lipid …

Allostery is a pervasive principle to regulate protein function. Growing evidence suggests
that also DNA is capable of transmitting allosteric signals. Yet, whether and how DNA-…

. Membrane transporters… … need to cycle through different conformations in order to perform
function. Using state-of-the-art smFRET tools, H. Hofmann, C. Lçw, and co-workers reveal …