User profiles for Feng Geng

Feng Geng

Professor, Harbin Medical University Cancer Hospital
Verified email at hrbmu.edu.cn
Cited by 2120

A prion-like domain in ELF3 functions as a thermosensor in Arabidopsis

…, M Gao, D Derwort, CS Silva, X Lai, E Pierre, F Geng… - Nature, 2020 - nature.com
Temperature controls plant growth and development, and climate change has already
altered the phenology of wild plants and crops 1 . However, the mechanisms by which plants …

[HTML][HTML] Lipid metabolism reprogramming and its potential targets in cancer

C Cheng, F Geng, X Cheng, D Guo - Cancer communications, 2018 - Springer
Reprogramming of lipid metabolism is a newly recognized hallmark of malignancy. Increased
lipid uptake, storage and lipogenesis occur in a variety of cancers and contribute to rapid …

Single-cell proteomic chip for profiling intracellular signaling pathways in single tumor cells

Q Shi, L Qin, W Wei, F Geng, R Fan… - Proceedings of the …, 2012 - National Acad Sciences
We describe a microchip designed to quantify the levels of a dozen cytoplasmic and membrane
proteins from single cells. We use the platform to assess protein–protein interactions …

Red/near‐infrared thermally activated delayed fluorescence OLEDs with near 100% internal quantum efficiency

…, K Wang, C Cao, J Yu, S Li, FX Geng… - Angewandte …, 2019 - Wiley Online Library
Developing red thermally activated delayed fluorescence (TADF) emitters, attainable for
both high‐efficient red organic light‐emitting diodes (OLEDs) and non‐doped deep red/near‐…

[PDF][PDF] Targeting DGAT1 ameliorates glioblastoma by increasing fat catabolism and oxidative stress

X Cheng, F Geng, M Pan, X Wu, Y Zhong, C Wang… - Cell metabolism, 2020 - cell.com
Glioblastoma (GBM), a mostly lethal brain tumor, acquires large amounts of free fatty acids (FAs)
to promote cell growth. But how the cancer avoids lipotoxicity is unknown. Here, we …

Inhibition of SOAT1 suppresses glioblastoma growth via blocking SREBP-1–mediated lipogenesis

F Geng, X Cheng, X Wu, JY Yoo, C Cheng, JY Guo… - Clinical Cancer …, 2016 - AACR
Purpose: Elevated lipogenesis regulated by sterol regulatory element-binding protein-1 (SREBP-1),
a transcription factor playing a central role in lipid metabolism, is a novel …

An RNA thermoswitch regulates daytime growth in Arabidopsis

…, M Balcerowicz, M Di Antonio, KE Jaeger, F Geng… - Nature plants, 2020 - nature.com
Temperature is a major environmental cue affecting plant growth and development. Plants
often experience higher temperatures in the context of a 24 h day–night cycle, with …

[PDF][PDF] Glucose-mediated N-glycosylation of SCAP is essential for SREBP-1 activation and tumor growth

C Cheng, P Ru, F Geng, J Liu, JY Yoo, X Wu, X Cheng… - Cancer cell, 2015 - cell.com
Tumorigenesis is associated with increased glucose consumption and lipogenesis, but how
these pathways are interlinked is unclear. Here, we delineate a pathway in which EGFR …

Thio-glucose bound gold nanoparticles enhance radio-cytotoxic targeting of ovarian cancer

F Geng, K Song, JZ Xing, C Yuan, S Yan… - …, 2011 - iopscience.iop.org
The treatment of ovarian cancer has traditionally been intractable, and required novel
approaches to improve therapeutic efficiency. This paper reports that thio-glucose bound gold …

Managing locally excited and charge‐transfer triplet states to facilitate up‐conversion in red TADF emitters that are available for both vacuum‐and solution‐processes

…, X Zhang, M Zhang, YZ Shi, J Yu, FX Geng… - Angewandte …, 2021 - Wiley Online Library
Developing red thermally activated delayed fluorescence (TADF) emitters for high‐performance
OLEDs is still facing great challenge. Herein, three red TADF emitters, pDBBPZ‐DPXZ, …