The full neutrophil heterogeneity and differentiation landscape remains incompletely characterized.
Here, we profiled >25,000 differentiating and mature mouse neutrophils using single-…

The delivery of therapeutics to the central nervous system remains a major challenge in part
due to the presence of the blood–brain barrier (BBB). Recently, cell-derived vesicles, …

Mesenchymal stem cell (MSC)-derived exosomes have been recognized as new candidates
for cell-free treatment of various diseases. However, maintaining the retention and stability …

Neutrophils play an essential role in the defense against bacterial infections and orchestrate
both the innate and adaptive immune responses. With their abundant numbers, diverse …

Neutrophil homeostasis, migration, and recruitment must be precisely regulated. The CXCR2
signaling pathway is a potential target for modifying neutrophil dynamics in inflammatory …

Background/Aims: Mesenchymal stem cells (MSCs) have been implicated in antitumor
therapy for hematopoietic and non-hematopoietic tumors. Cell-contact and soluble factors are …

Candida albicans is the most common cause of fungal sepsis. Inhibition of inflammasome
activity confers resistance to polymicrobial and LPS-induced sepsis; however, inflammasome …

Introduction Mesenchymal stem cells (MSCs) represent a heterogeneous cell population that
is promising for regenerative medicine. The present study was designed to assess whether …

Systemic administration of mesenchymal stem cells (MSCs) affords the potential to ameliorate
the symptoms of Multiple Sclerosis (MS) in both preclinical and clinical studies. However, …

Aplastic anemia (AA) is generally considered as an immune-mediated bone marrow failure
syndrome with defective hematopoietic stem cells (HSCs) and marrow microenvironment. …