Tissues undergoing morphogenesis impose mechanical effects on one another. How
developmental programs adapt to or take advantage of these effects remains poorly explored. Here…

Epithelial cells acquire functionally important shapes (eg, squamous, cuboidal, columnar)
during development. Here, we combine theory, quantitative imaging, and perturbations to …

Sharply delineated domains of cell types arise in developing tissues under instruction of
inductive signal (morphogen) gradients, which specify distinct cell fates at different signal levels. …

Mammalian embryos transiently exhibit aerobic glycolysis (Warburg effect), a metabolic
adaptation also observed in cancer cells. The role of this particular type of metabolism during …

In mammalian embryonic stem cells, the acquisition of pluripotency is dependent on Nanog,
but the in vivo analysis of Nanog has been hampered by its requirement for early mouse …

During the development of the spinal cord, proliferative neural progenitors differentiate into
postmitotic neurons with distinct fates. How cells switch from progenitor states to …

The vertebrate anteroposterior axis forms through elongation of multiple tissues during
embryogenesis. This process is based on tissue-autonomous mechanisms of force generation …

The quantification of cell shape, cell migration, and cell rearrangements is important for
addressing classical questions in developmental biology such as patterning and tissue …

Formation of the body of vertebrate embryos proceeds sequentially by posterior addition of
tissues from the tail bud. Cells of the tail bud and the posterior presomitic mesoderm, which …

The neural tube is an important model system of morphogenesis representing the
developmental module of out-of-plane epithelial deformation. As the embryonic precursor of the …