Defects in membrane trafficking are hallmarks of neurodegeneration. Rab GTPases are key
regulators of membrane trafficking. Alterations of Rab GTPases, or the membrane …

Microglia play a role in the emergence and preservation of a healthy brain microenvironment.
Dysfunction of microglia has been associated with neurodevelopmental and …

Human brain organoids provide unique platforms for modeling several aspects of human
brain development and pathology. However, current brain organoid systems mostly lack the …

Neurons are highly polarized cells that require continuous turnover of membrane proteins at
axon terminals to develop, function, and survive. Yet, it is still unclear whether membrane …

Variability of synapse numbers and partners despite identical genes reveals the limits of
genetic determinism. Here, we use developmental temperature as a non-genetic perturbation to …

In the central nervous system (CNS), microglia carry out multiple tasks related to brain
development, maintenance of brain homeostasis, and function of the CNS. Recent advanced in …

… Eugene Jennifer Jin and Ferdi Ridvan Kiral contributed … Eugene Jennifer Jin and Ferdi
Ridvan Kiral contributed equally … Eugene Jennifer Jin and Ferdi Ridvan Kiral contributed equally …

Region specific brain organoids are brain organoids derived by patterning protocols using
extrinsic signals as opposed to cerebral organoids obtained by self-patterning. The main …

Brain wiring is remarkably precise, yet most neurons readily form synapses with incorrect
partners when given the opportunity. Dynamic axon-dendritic positioning can restrict …

The diencephalon, an integral component of the forebrain, governs a spectrum of crucial
functions, ranging from sensory processing to emotional regulation. Yet, unraveling its unique …