Mutational signature in colorectal cancer caused by genotoxic pks+E. coli

…, F Manders, G Dalmasso, PB Stege, FL Paganelli… - Nature, 2020 - nature.com
Various species of the intestinal microbiota have been associated with the development of
colorectal cancer 1 , 2 , but it has not been demonstrated that bacteria have a direct role in the …

Antibacterial behavior of additively manufactured porous titanium with nanotubular surfaces releasing silver ions

S Amin Yavari, L Loozen, FL Paganelli… - … applied materials & …, 2016 - ACS Publications
Additive manufacturing (3D printing) has enabled fabrication of geometrically complex and
fully interconnected porous biomaterials with huge surface areas that could be used for …

Optimizing future treatment of enterococcal infections: attacking the biofilm?

FL Paganelli, RJ Willems, HL Leavis - Trends in microbiology, 2012 - cell.com
Enterococcus faecalis and Enterococcus faecium are among the leading causative agents of
nosocomial infections and are infamous for their resistance to many antibiotics. They cause …

[HTML][HTML] Genome-Wide Identification of Ampicillin Resistance Determinants in Enterococcus faecium

X Zhang, FL Paganelli, D Bierschenk, A Kuipers… - PLoS …, 2012 - journals.plos.org
Enterococcus faecium has become a nosocomial pathogen of major importance, causing
infections that are difficult to treat owing to its multi-drug resistance. In particular, resistance to …

[HTML][HTML] Roux-Y gastric bypass and sleeve gastrectomy directly change gut microbiota composition independent of surgery type

FL Paganelli, M Luyer, CM Hazelbag, HW Uh… - Scientific reports, 2019 - nature.com
Bariatric surgery in morbid obesity, either through sleeve gastrectomy (SG) or Roux-Y gastric
bypass (RYGB), leads to sustainable weight loss, improvement of metabolic disorders and …

BCG Vaccination of health care workers does not reduce SARS-CoV-2 infections nor infection severity or duration: a randomized placebo-controlled trial

…, F van der Klis, D van Baarle, FL Paganelli… - MBio, 2023 - Am Soc Microbiol
Bacillus Calmette-Guerin (BCG) vaccination has been hypothesized to reduce severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, severity, and/or duration via …

Antibiotic-driven dysbiosis mediates intraluminal agglutination and alternative segregation of Enterococcus faecium from the intestinal epithelium

…, H Kemperman, MRC Rogers, FL Paganelli… - MBio, 2015 - Am Soc Microbiol
The microbiota of the mammalian gastrointestinal tract is a complex ecosystem of bacterial
communities that continuously interact with the mucosal immune system. In a healthy host, …

CRISPR-Cas is associated with fewer antibiotic resistance genes in bacterial pathogens

E Pursey, T Dimitriu, FL Paganelli… - … of the Royal …, 2022 - royalsocietypublishing.org
The acquisition of antibiotic resistance (ABR) genes via horizontal gene transfer (HGT) is a
key driver of the rise in multidrug resistance amongst bacterial pathogens. Bacterial defence …

[HTML][HTML] Low IgA associated with oropharyngeal microbiota changes and lung disease in primary antibody deficiency

…, VASH Dalm, PM Van Hagen, FL Paganelli… - Frontiers in …, 2020 - frontiersin.org
Common Variable Immunodeficiency (CVID) and X-linked agammaglobulinemia (XLA) are
primary antibody deficiencies characterized by hypogammaglobulinemia and recurrent …

Enterococcus faecium Biofilm Formation: Identification of Major Autolysin AtlAEfm, Associated Acm Surface Localization, and AtlAEfm-Independent Extracellular DNA …

FL Paganelli, RJL Willems, P Jansen, A Hendrickx… - MBio, 2013 - Am Soc Microbiol
Enterococcus faecium is an important multidrug-resistant nosocomial pathogen causing
biofilm-mediated infections in patients with medical devices. Insight into E. faecium biofilm …