In response to stress, human cells coordinately downregulate transcription and translation
of housekeeping genes. To downregulate transcription, the negative elongation factor (NELF) …

The precise regulation of RNA Polymerase II (Pol II) transcription after genotoxic stress is
crucial for proper execution of the DNA damage-induced stress response. While stalling of Pol …

The purinergic P2X7 receptor (P2X7R) has attracted considerable interest as a potential
target for various central nervous system (CNS) pathologies including affective and …

Understanding how genotypes are linked to phenotypes is important in biomedical and
evolutionary studies. The chaperone heat-shock protein 90 (HSP90) buffers genetic variation by …

A single nucleotide polymorphism substitution from glutamine (Gln, Q) to arginine (Arg, R) at
codon 460 of the purinergic P2X7 receptor (P2X7R) has repeatedly been associated with …

Proteotoxic stress such as heat shock causes heat-shock factor (HSF)-dependent
transcriptional upregulation of chaperones. Heat shock also leads to a rapid and reversible …

Molecular chaperones are critical for protein homeostasis and are implicated in several human
pathologies such as neurodegeneration and cancer. While the binding of chaperones to …

Our current understanding of biomolecular condensate formation is largely based on
observing the final near-equilibrium condensate state. Despite expectations from classical …

Molecular chaperones such as heat-shock proteins (HSPs) help in protein folding. Their
function in the cytosol has been well studied. Notably, chaperones are also present in the …

FK506-binding protein 51 (FKBP51) regulates the activity of the glucocorticoid receptor (GR),
and is therefore a key mediator of the biological actions of glucocorticoids. However, the …