Nanopores are powerful single-molecule tools for label-free sensing of nanoscale molecules
including DNA that can be used for building designed nanostructures and performing …

Multiplexed nucleic acid sensing methods with high specificity are vital for clinical diagnostics
and infectious disease control, especially in the postpandemic era. Nanopore sensing …

Identifying RNA transcript isoforms requires intricate protocols that suffer from various
enzymatic biases. Here we design three-dimensional molecular constructs that enable …

Transcription, a critical process in molecular biology, has found many applications in RNA
synthesis, including mRNA vaccines and RNA therapeutics. However, current RNA …

Extracellular vesicles (EVs) are emerging as important mediators of cell–cell communication
as well as potential disease biomarkers and drug delivery vehicles. However, the …

Assembly of DNA structures based on hybridization like split G-quadruplex (GQ) have great
potential for the base-pair specific identification of nucleic acid targets. Herein, we combine …

Emerging technologies use cell plasma membrane vesicles or “blebs” as an intermediate to
form molecularly complete, planar cell surface mimetics that are compatible with a variety of …

G-quadruplexes (Gqs) are guanine-rich DNA structures formed by single-stranded DNA.
They are of paramount significance to gene expression regulation, but also drug targets for …

Digitally encoded deoxyribonucleic acid (DNA) nanostructures built via DNA self‐assembly
have established applications in multiplexed biosensing and storing digital information. …

The toehold-mediated strand displacement reaction (SDR) is a powerful enzyme-free tool
for molecular manipulation, DNA computing, signal amplification, etc. However, precise …