Transcriptional control in large genomes often requires looping interactions between distal
DNA elements, such as enhancers and target promoters. Current chromosome conformation …

The mammalian genome harbors up to one million regulatory elements often located at
great distances from their target genes. Long-range elements control genes through physical …

The Polycomb repressive complexes PRC1 and PRC2 maintain embryonic stem cell (ESC)
pluripotency by silencing lineage-specifying developmental regulator genes 1 . Emerging …

The centriole and basal body (CBB) structure nucleates cilia and flagella, and is an essential
component of the centrosome, underlying eukaryotic microtubule-based motility, cell …

Rab proteins are small GTPases that act as essential regulators of vesicular trafficking. 44
subfamilies are known in humans, performing specific sets of functions at distinct subcellular …

Dosage compensation in Drosophila is an epigenetic phenomenon utilizing proteins and
long noncoding RNAs (lncRNAs) for transcriptional upregulation of the male X chromosome. …

During interphase, the eukaryotic genome is organized into chromosome territories that are
spatially segregated into compartment domains. The extent to which interacting domains or …

Proper gene expression requires coordinated interplay among transcriptional coactivators,
transcription factors and the general transcription machinery. We report here that MSL1, a …

Drought stress induces a vast array of responses in plants that require the use of integrative
and multidisciplinary approaches to understand the different levels of regulation. Holistic …

The genome is organized into chromosome territories that are themselves spatially segregated
in A and B compartments. The extent to which interacting compartment domains and …